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dc.contributor.authorShin, Nari
dc.contributor.authorJo, Hong-Jae
dc.contributor.authorKim, Woo-Kyung
dc.contributor.authorPark, Won-Young
dc.contributor.authorLee, Jeong-Hee
dc.contributor.authorShin, Dong Hun
dc.contributor.authorChoi, Kyung Un
dc.contributor.authorKim, Jee-Yeon
dc.contributor.authorLee, Chang-Hun
dc.contributor.authorSol, Mee Young
dc.contributor.authorJeon, Tae Yong
dc.contributor.authorKim, Dae Hyun
dc.contributor.authorHuh, Gi-Young
dc.contributor.authorKim, Gwang Ha
dc.contributor.authorLauwers, Gregory Y.
dc.contributor.authorPark, Do Youn
dc.date.accessioned2018-03-26T17:38:08Z
dc.date.issued2011
dc.identifier.citationShin, Nari, Hong-Jae Jo, Woo-Kyung Kim, Won-Young Park, Jeong-Hee Lee, Dong Hun Shin, Kyung Un Choi, et al. 2011. “Gastric Pit Dysplasia in Adjacent Gastric Mucosa in 414 Gastric Cancers.” The American Journal of Surgical Pathology 35 (7) (July): 1021–1029. doi:10.1097/pas.0b013e31821ec495.en_US
dc.identifier.issn0147-5185en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35136024
dc.description.abstractDespite wide acceptance of the chronic gastritis-intestinal metaplasia-dysplasia-carcinoma sequence, especially for intestinal-type gastric adenocarcinoma, the precise nature of the subtle precursor lesions of gastric cancer remains to be delineated. For example, pit dysplasia with surface foveolar maturation is not well defined, nor is its prevalence and biological characteristics well characterized. We have evaluated the surrounding gastric mucosa of 414 gastric cancers for the presence of gastric pit dysplasia. We investigated its relationship with various clinicopathological and immunophenotypic features of gastric adenocarcinoma, as well as the severity and extent of any surrounding gastritis and intestinal metaplasia. p53 expression and Ki-67 proliferation index were also evaluated. We have found that 21.0% (n=87) of gastric cancer cases showed pit dysplasia in adjacent gastric mucosa. Gastric cancers with pit dysplasia were significantly associated with older age, male sex, body/fundic location, and intestinal histologic type (P<0.05). Interestingly, gastric mucin-containing intestinal metaplasia (incomplete intestinal metaplasia) was highly associated with adenocarcinoma with pit dysplasia (P=0.000). In addition, MUC6 expression in gastric adenocarcinoma was associated with pit dysplasia (P=0.036). p53 overexpression and increased Ki-67 proliferation index were more evident in gastric pit dysplasia compared with adjacent gastric mucosa. We suggest that gastric pit dysplasia is an important candidate precursor of gastric adenocarcinoma and may represent another morphologic step in the pathogenesis of gastric adenocarcinoma, especially of intestinal type. More detailed prospective studies are needed to determine the precise significance of these findings.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1097/PAS.0b013e31821ec495en_US
dash.licenseMETA_ONLY
dc.titleGastric Pit Dysplasia in Adjacent Gastric Mucosa in 414 Gastric Cancersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe American Journal of Surgical Pathologyen_US
dash.depositing.authorLauwers, Gregory Y.
dash.embargo.until10000-01-01
dc.identifier.doi10.1097/PAS.0b013e31821ec495*
workflow.legacycommentsnoap.needmanen_US
dash.authorsorderedfalse
dash.contributor.affiliatedKim, Dae Hyun
dash.contributor.affiliatedLauwers, Gregory Y.


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