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dc.contributor.authorLi, Yuan
dc.contributor.authorChang, Xiaoyan
dc.contributor.authorZhou, Weixun
dc.contributor.authorXiao, Yun
dc.contributor.authorNakatsuka, Laura N.
dc.contributor.authorChen, Jie
dc.contributor.authorLauwers, Gregory Y.
dc.date.accessioned2018-03-26T17:47:00Z
dc.date.issued2013
dc.identifier.citationLi, Yuan, Xiaoyan Chang, Weixun Zhou, Yu Xiao, Laura N. Nakatsuka, Jie Chen, and Gregory Y. Lauwers. 2013. “Gastric Intestinal Metaplasia with Basal Gland Atypia: a Morphological and Biologic Evaluation in a Large Chinese Cohort.” Human Pathology 44 (4) (April): 578–590. doi:10.1016/j.humpath.2012.07.002.en_US
dc.identifier.issn0046-8177en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35136029
dc.description.abstractGastric intestinal metaplasia can display cytoarchitectural atypia that falls short of qualifying for dysplasia but can be classified as indefinite for dysplasia. Yet few studies have evaluated the prevalence, the morphologic, and biologic characteristics of this variant. Out of a cohort of 554 biopsies with chronic atrophic gastritis and/or dysplasia, we categorized the cases as either (1) simple intestinal metaplasia; (2) intestinal metaplasia with hyperplasia; (3) intestinal metaplasia with basal gland atypia; and (4) gastric dysplasia. The relationship between the subtypes and various clinicopathologic features, mucin immunophenotypes, and biologic characteristics was evaluated. The final cohort consisted of 424 cases of simple intestinal metaplasia, 93 intestinal metaplasia with hyperplasia, 16 intestinal metaplasia with basal gland atypia, and 21 gastric dysplasia. Intestinal metaplasia with basal gland atypia had a prevalence of 2.8% and similar to gastric dysplasia, 3.7%. Both of these lesions were similar in body/fundus distribution (12.5%) and paucity of goblet cells (68.8%). Intestinal metaplasia with basal gland atypia and gastric dysplasia seem to share some biologic similarities but with a lower frequency of alpha-methylacyl-CoA racemase expression (25% versus 62%), p53 expression (6.3% versus 47.6%), and increased Ki-67 index on surface/pit and isthmus in intestinal metaplasia with basal gland atypia. Alternatively, simple intestinal metaplasia and intestinal metaplasia with hyperplasia did not differ statistically with regard to the various characteristics evaluated. We concluded that gastric intestinal metaplasia can be divided into 2 broad categories that are readily defined by cytoarchitectural and biologic characteristics. Based on the characteristics of intestinal metaplasia with basal gland atypia and in keeping with others, we confirm that this subtype could represent a preneoplastic lesion that needs further evaluation.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.humpath.2012.07.002en_US
dash.licenseMETA_ONLY
dc.subjectstomachen_US
dc.subjectadenocarcinomaen_US
dc.subjectintestinal metaplasiaen_US
dc.subjectbasal gland atypiaen_US
dc.subjectdysplasiaen_US
dc.subjectgastric pit dysplasiaen_US
dc.titleGastric intestinal metaplasia with basal gland atypia: a morphological and biologic evaluation in a large Chinese cohorten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalHuman Pathologyen_US
dash.depositing.authorLauwers, Gregory Y.
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/j.humpath.2012.07.002*
workflow.legacycommentsnoap.needmanen_US
dash.contributor.affiliatedXiao, Yun
dash.contributor.affiliatedChen, Jie
dash.contributor.affiliatedLauwers, Gregory Y.


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