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dc.contributor.authorHuang, Qin
dc.contributor.authorShi, Jiong
dc.contributor.authorFeng, Anning
dc.contributor.authorFan, Xiangshan
dc.contributor.authorZhang, Lihua
dc.contributor.authorMashimo, Hiroshi
dc.contributor.authorCohen, Daniel Michael
dc.contributor.authorLauwers, Gregory Y.
dc.date.accessioned2018-03-27T17:34:40Z
dc.date.issued2010
dc.identifier.citationHuang, Qin, Jiong Shi, Anning Feng, Xiangshan Fan, Lihua Zhang, Hiroshi Mashimo, Daniel Cohen, and Gregory Lauwers. 2010. “Gastric Cardiac Carcinomas Involving the Esophagus Are More Adequately Staged as Gastric Cancers by the 7th Edition of the American Joint Commission on Cancer Staging System.” Modern Pathology 24 (1) (September 17): 138–146. doi:10.1038/modpathol.2010.183.en_US
dc.identifier.issn0893-3952en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35140959
dc.description.abstractBackground: The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined. Methods: To better characterize mutations in established known oncogenes and tumor suppressor genes we tested a mass spectrometric based platform to interrogate common cancer associated mutations across a panel of 77 formalin fixed paraffin embedded archived BTC cases. Results: Mutations among three genes, KRAS, NRAS and PIK3CA were confirmed in this cohort. Activating mutations in PIK3CA were identified exclusively in GBC (4/32, 12.5%). KRAS mutations were identified in 3 (13%) intra-hepatic cholangiocarcinomas and 1 (33%) perihillar cholangiocarcinoma but were not identified in gallbladder carcinomas and extra-hepatic cholangiocarcinoma. Conclusions: The presence of activating mutations in PIK3CA specifically in GBC has clinical implications in both the diagnosis of this cancer type, as well as the potential utility of targeted therapies such as PI3 kinase inhibitors.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionofdoi:10.1038/modpathol.2010.183en_US
dash.licenseMETA_ONLY
dc.subjectcanceren_US
dc.subjectesophagusen_US
dc.subjectgastroesophageal junctionen_US
dc.subjectstagingen_US
dc.subjectstomachen_US
dc.titleGastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging Systemen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalModern Pathologyen_US
dash.depositing.authorLauwers, Gregory Y.
dash.embargo.until10000-01-01
dc.identifier.doi10.1038/modpathol.2010.183*
workflow.legacycommentsnoap.needmanen_US
dash.contributor.affiliatedCohen, Daniel Michael
dash.contributor.affiliatedMashimo, Hiroshi
dash.contributor.affiliatedHuang, Qin
dash.contributor.affiliatedLauwers, Gregory Y.


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