dc.contributor.author | Rocha, V. Z. | |
dc.contributor.author | Folco, Eduardo | |
dc.contributor.author | Ozdemir, Cafer | |
dc.contributor.author | Sheikine, Y. | |
dc.contributor.author | Christen, T. | |
dc.contributor.author | Sukhova, Galina K. | |
dc.contributor.author | Tang, E. H. C. | |
dc.contributor.author | Bittencourt, M. S. | |
dc.contributor.author | Santos, R. D. | |
dc.contributor.author | Luster, Andrew David | |
dc.contributor.author | Cohen, David E | |
dc.contributor.author | Libby, Peter | |
dc.date.accessioned | 2018-03-27T18:48:14Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Rocha, V. Z., E. J. Folco, C. Ozdemir, Y. Sheikine, T. Christen, G. K. Sukhova, E. H. C. Tang, et al. 2014. “CXCR3 Controls T-Cell Accumulation in Fat Inflammation.” Arteriosclerosis, Thrombosis, and Vascular Biology 34 (7) (May 8): 1374–1381. doi:10.1161/atvbaha.113.303133. | en_US |
dc.identifier.issn | 1079-5642 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:35141009 | |
dc.description.abstract | Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine receptor CXCR3 participates in T-cell accumulation in AT of obese mice and thus in the regulation of local inflammation and systemic metabolism.
Approach and Results—Obese wild-type mice exhibited higher mRNA expression of CXCR3 in periepididymal AT-derived stromal vascular cells compared with lean mice. We evaluated the function of CXCR3 in AT inflammation in vivo using CXCR3-deficient and wild-type control mice that consumed a high-fat diet. Periepididymal AT from obese CXCR3-deficient mice contained fewer T cells than obese controls after 8 and 16 weeks on high-fat diet, as assessed by flow cytometry. Obese CXCR3-deficient mice had greater glucose tolerance than obese controls after 8 weeks, but not after 16 weeks. CXCR3-deficient mice fed high-fat diet had reduced mRNA expression of proinflammatory mediators, such as monocyte chemoattractant protein-1 and regulated on activation, normal T cell expressed and secreted, and anti-inflammatory genes, such as Foxp3, IL-10, and arginase-1 in periepididymal AT, compared with obese controls.
Conclusions—These results demonstrate that CXCR3 contributes to T-cell accumulation in periepididymal AT of obese mice. Our results also suggest that CXCR3 regulates the accumulation of distinct subsets of T cells and that the ratio between these functional subsets across time likely modulates local inflammation and systemic metabolism. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | en_US |
dc.relation.isversionof | doi:10.1161/ATVBAHA.113.303133 | en_US |
dash.license | META_ONLY | |
dc.subject | fats | en_US |
dc.subject | inflammation | en_US |
dc.subject | obesity | en_US |
dc.title | CXCR3 Controls T-Cell Accumulation in Fat Inflammation | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Arteriosclerosis, Thrombosis, and Vascular Biology | en_US |
dash.depositing.author | Libby, Peter | |
dash.embargo.until | 10000-01-01 | |
dc.identifier.doi | 10.1161/ATVBAHA.113.303133 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Folco, Eduardo | |
dash.contributor.affiliated | Ozdemir, Cafer | |
dash.contributor.affiliated | Cohen, David E. | |
dash.contributor.affiliated | Sukhova, Galina | |
dash.contributor.affiliated | Luster, Andrew | |
dash.contributor.affiliated | Libby, Peter | |