Show simple item record

dc.contributor.authorMylonakis, E.
dc.contributor.authorEngelbert, M.
dc.contributor.authorQin, X.
dc.contributor.authorSifri, C. D.
dc.contributor.authorMurray, B. E.
dc.contributor.authorAusubel, Frederick M.
dc.contributor.authorGilmore, Michael S.
dc.contributor.authorCalderwood, Stephen Beaven
dc.date.accessioned2018-03-27T20:32:37Z
dc.date.issued2002
dc.identifier.citationMylonakis, E., M. Engelbert, X. Qin, C. D. Sifri, B. E. Murray, F. M. Ausubel, M. S. Gilmore, and S. B. Calderwood. 2002. The Enterococcus Faecalis fsrB Gene, a Key Component of the Fsr Quorum-Sensing System, Is Associated with Virulence in the Rabbit Endophthalmitis Model. Infection and Immunity 70, no. 8: 4678–4681. doi:10.1128/iai.70.8.4678-4681.2002.en_US
dc.identifier.issn0019-9567en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35141063
dc.description.abstractWe used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.isversionofdoi:10.1128/IAI.70.8.4678-4681.2002en_US
dash.licenseLAA
dc.titleThe Enterococcus faecalis fsrB Gene, a Key Component of the fsr Quorum-Sensing System, Is Associated with Virulence in the Rabbit Endophthalmitis Modelen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalInfection and Immunityen_US
dash.depositing.authorGilmore, Michael S.
dc.date.available2018-03-27T20:32:37Z
dc.identifier.doi10.1128/IAI.70.8.4678-4681.2002*
workflow.legacycommentsnoap.needmanen_US
dash.contributor.affiliatedAusubel, Frederick
dash.contributor.affiliatedCalderwood, Stephen
dash.contributor.affiliatedGilmore, Michael


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record