Lower Left Temporal Lobe MRI Volumes in Patients With First-Episode Schizophrenia Compared With Psychotic Patients With First-Episode Affective Disorder and Normal Subjects
View/ Open
ajp%2E155%2E10%2E1384.pdf (464.4Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Hirayasu, Yoshio
Salisbury, Dean F.
Fischer, Iris A.
Mazzoni, Paola
Kisler, Tanya
Arakaki, Hajime
Kwon, Jun Soo
Anderson, Jane E.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1176/ajp.155.10.1384Metadata
Show full item recordCitation
Hirayasu, Yoshio, Martha E. Shenton, Dean F. Salisbury, Chandlee C. Dickey, Iris A. Fischer, Paola Mazzoni, Tanya Kisler, et al. 1998. “Lower Left Temporal Lobe MRI Volumes in Patients With First-Episode Schizophrenia Compared With Psychotic Patients With First-Episode Affective Disorder and Normal Subjects.” AJP 155 (10) (October): 1384–1391. doi:10.1176/ajp.155.10.1384.Abstract
Objective:Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal lobe structures. However, the specificity to schizophrenia and the roles of chronic morbidity and neuroleptic treatment in these abnormalities remain unclear. Method:Magnetic resonance (1.5-T) scans were obtained from 33 patients with first-episode psychosis and 18 age-matched normal comparison subjects, all right-handed. Sixteen of the patients were diagnosed with affective disorder and 17 with schizophrenia. Results:Quantitative volumetric analysis showed that the patients with first-episode schizophrenia had significantly smaller gray matter volume in the left posterior superior temporal gyrus than did the patients with first-episode affective psychosis or the comparison subjects, with a significant left-less-than-right asymmetry. The schizophrenic patients also showed a smaller gray matter volume of the left posterior amygdala-hippocampal complex than the comparison subjects. Both the patients with schizophrenia and those with affective psychosis had significant left-less-than-right asymmetry of the posterior amygdala-hippocampal complex.Conclusions:These findings suggest that temporal lobe abnormalities are present at the first hospitalization for schizophrenia and that low volume of the left posterior superior temporal gyrus gray matter is specific to schizophrenia compared with affective disorder.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:35647949
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)