Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Author
Schlein, Christian
Johann, Kornelia
Eguchi, Kosei
Fischer, Alexander W
Nguyen, Truc B
Bruns, Oliver T
Franke, Daniel
Bawendi, Moungi G
Leiria, Luiz O
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1002/oby.21721Metadata
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Bartelt, Alexander, Scott B Widenmaier, Christian Schlein, Kornelia Johann, Renata L S Goncalves, Kosei Eguchi, Alexander W Fischer, et al. 2018. “Brown Adipose Tissue Thermogenic Adaptation Requires Nrf1-Mediated Proteasomal Activity.” Nature Medicine 24 (3) (February 5): 292–303. doi:10.1038/nm.4481.Abstract
ObjectiveBrown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet‐induced thermogenesis and mitigates weight gain from prolonged overeating. Therefore, this study investigated whether BAT activity is related to metabolic adaptation arising from 8 weeks of overfeeding in humans.
Methods
Fourteen men (aged 24 ± 3 years, BMI 24.5 ± 1.6 kg/m2) were overfed by 40% for 8 weeks. Before and after, energy expenditure and metabolic adaptation were measured by whole‐room respiratory calorimetry. A marker of BAT activity was measured using infrared imaging of the supraclavicular BAT depot.
Results
At the end of 8 weeks of overfeeding, metabolic adaptation—defined as the percent increase in sleeping energy expenditure beyond that expected from weight gain—rose from −0.9 ± 3.9% to 4.7 ± 5.6% (P = 0.001). However, BAT thermal activity was unchanged (P = 0.81). Moreover, BAT thermal activity did not correlate with the degree of metabolic adaptation (P = 0.32) or with the change in body weight (P = 0.51).
Conclusions
BAT thermal activity does not change in response to overfeeding, nor does it correlate with adaptive thermogenesis. Our data suggest that BAT does not mediate metabolic adaptation to overeating in humans.
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