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dc.contributor.authorKivimäki, Mikaen_US
dc.contributor.authorNyberg, Solja T.en_US
dc.contributor.authorBatty, G. Daviden_US
dc.contributor.authorKawachi, Ichiroen_US
dc.contributor.authorJokela, Markusen_US
dc.contributor.authorAlfredsson, Larsen_US
dc.contributor.authorBjorner, Jakob B.en_US
dc.contributor.authorBorritz, Marianneen_US
dc.contributor.authorBurr, Hermannen_US
dc.contributor.authorDragano, Nicoen_US
dc.contributor.authorFransson, Eleonor I.en_US
dc.contributor.authorHeikkilä, Katriinaen_US
dc.contributor.authorKnutsson, Andersen_US
dc.contributor.authorKoskenvuo, Markkuen_US
dc.contributor.authorKumari, Meenaen_US
dc.contributor.authorMadsen, Ida E.H.en_US
dc.contributor.authorNielsen, Martin L.en_US
dc.contributor.authorNordin, Mariaen_US
dc.contributor.authorOksanen, Tuulaen_US
dc.contributor.authorPejtersen, Jan H.en_US
dc.contributor.authorPentti, Jaanaen_US
dc.contributor.authorRugulies, Reineren_US
dc.contributor.authorSalo, Paulaen_US
dc.contributor.authorShipley, Martin J.en_US
dc.contributor.authorSuominen, Sakarien_US
dc.contributor.authorTheorell, Töresen_US
dc.contributor.authorVahtera, Jussien_US
dc.contributor.authorWesterholm, Peteren_US
dc.contributor.authorWesterlund, Hugoen_US
dc.contributor.authorSteptoe, Andrewen_US
dc.contributor.authorSingh-Manoux, Archanaen_US
dc.contributor.authorHamer, Marken_US
dc.contributor.authorFerrie, Jane E.en_US
dc.contributor.authorVirtanen, Mariannaen_US
dc.contributor.authorTabak, Adam G.en_US
dc.date.accessioned2018-04-19T14:26:14Z
dc.date.issued2017en_US
dc.identifier.citationKivimäki, M., S. T. Nyberg, G. D. Batty, I. Kawachi, M. Jokela, L. Alfredsson, J. B. Bjorner, et al. 2017. “Long working hours as a risk factor for atrial fibrillation: a multi-cohort study.” European Heart Journal 38 (34): 2621-2628. doi:10.1093/eurheartj/ehx324. http://dx.doi.org/10.1093/eurheartj/ehx324.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35982263
dc.description.abstractAbstract Aims Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (≥55 per week) and those working standard 35–40 h/week. Methods and results In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991–2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI = 1.13–1.80, P = 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I2 = 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N = 2006, hazard ratio = 1.36, 95% CI = 1.05–1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association. Conclusion: Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.relation.isversionofdoi:10.1093/eurheartj/ehx324en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837794/pdf/en
dash.licenseLAAen_US
dc.subjectAtrial Fibrillationen
dc.subjectEditor's Choiceen
dc.subjectAtrial fibrillationen
dc.subjectLife stressen
dc.subjectRisk factorsen
dc.subjectCohort studyen
dc.titleLong working hours as a risk factor for atrial fibrillation: a multi-cohort studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEuropean Heart Journalen
dash.depositing.authorKawachi, Ichiroen_US
dc.date.available2018-04-19T14:26:14Z
dc.identifier.doi10.1093/eurheartj/ehx324*
dash.authorsorderedfalse
dash.contributor.affiliatedKawachi, Ichiro


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