High‐sensitivity C‐reactive protein, low‐density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial
View/ Open
Author
Hwang, You‐Cheol
Morrow, David A.
Cannon, Christopher P.
Liu, Yuyin
Bergenstal, Richard
Heller, Simon
Cushman, William
Bakris, George L.
Zannad, Faiez
White, William B.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1111/dom.13136Metadata
Show full item recordCitation
Hwang, Y., D. A. Morrow, C. P. Cannon, Y. Liu, R. Bergenstal, S. Heller, C. Mehta, et al. 2017. “High‐sensitivity C‐reactive protein, low‐density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial.” Diabetes, Obesity & Metabolism 20 (3): 654-659. doi:10.1111/dom.13136. http://dx.doi.org/10.1111/dom.13136.Abstract
Aims We sought to assess the risk of major adverse cardiovascular events (MACE) by utilizing high‐sensitivity C‐reactive protein (hsCRP) level and low‐density lipoprotein cholesterol (LDL‐C) in patients with type 2 diabetes and recent acute coronary syndrome. Materials and methods Study participants enrolled in the EXAMINE trial (Clinical trials registration number: NCT00968708) and were stratified by baseline hsCRP levels (<1, 1‐3 and >3 mg/L). They were also sub‐divided into 4 groups according to baseline hsCRP (≤3 or >3 mg/L) and achieved LDL‐C (<70 or ≥70 mg/dL) levels. Among 5380 patients, the MACE rate, a composite of cardiovascular death, non‐fatal acute myocardial infarction and non‐fatal stroke, was evaluated during the 30 months of follow‐up. Results: Cumulative incidence of MACE was 11.5% (119 events), 14.6% (209 events) and 18.4% (287 events) in patients with hsCRP levels of <1, 1 to 3 and >3 mg/L, respectively (P < .001). In patients with hsCRP >3 mg/L, the adjusted hazard ratio (95% confidence interval) was 1.42 (1.13, 1.78; P = .002) for MACE compared with patients with hsCRP <1 mg/L. MACE cumulative incidences were 11.0% (128 events), 14.4% (100 events), 15.6% (194 events) and 21.3% (182 events) in patients with low LDL‐C and low hsCRP, low LDL‐C and high hsCRP, high LDL‐C and low hsCRP, and high LDL‐C and high hsCRP levels, respectively (P < .001). Conclusions: Levels of hsCRP were associated with recurrent cardiovascular events in patients with type 2 diabetes and recent acute coronary syndrome, and this association appears to be independent of and additive to the achieved LDL‐C level.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836896/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982289
Collections
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)