Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
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Author
Cerhan, James R.
Berndt, Sonja I.
Vijai, Joseph
Ghesquières, Hervé
McKay, James
Wang, Sophia S.
Wang, Zhaoming
Yeager, Meredith
Conde, Lucia
Nieters, Alexandra
Cox, David
Burdett, Laurie
Monnereau, Alain
Flowers, Christopher R.
De Roos, Anneclaire J.
Brooks-Wilson, Angela R.
Lan, Qing
Severi, Gianluca
Melbye, Mads
Gu, Jian
Jackson, Rebecca D.
Kane, Eleanor
Teras, Lauren R.
Purdue, Mark P.
Vajdic, Claire M.
Spinelli, John J.
Giles, Graham G.
Albanes, Demetrius
Zucca, Mariagrazia
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Hutchinson, Amy
Zhi, Degui
Habermann, Thomas M.
Link, Brian K.
Novak, Anne J.
Dogan, Ahmet
Asmann, Yan W.
Liebow, Mark
Thompson, Carrie A.
Ansell, Stephen M.
Witzig, Thomas E.
Weiner, George J.
Veron, Amelie S.
Zelenika, Diana
Tilly, Hervé
Haioun, Corinne
Molina, Thierry Jo
Hjalgrim, Henrik
Glimelius, Bengt
Bracci, Paige M.
Riby, Jacques
Smith, Martyn T.
Holly, Elizabeth A.
Cozen, Wendy
Hartge, Patricia
Morton, Lindsay M.
Severson, Richard K.
Tinker, Lesley F.
North, Kari E.
Becker, Nikolaus
Benavente, Yolanda
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
Staines, Anthony
Lightfoot, Tracy
Crouch, Simon
Smith, Alex
Roman, Eve
Diver, W. Ryan
Offit, Kenneth
Zelenetz, Andrew
Klein, Robert J.
Villano, Danylo J.
Zheng, Tongzhang
Zhang, Yawei
Holford, Theodore R.
Kricker, Anne
Turner, Jenny
Southey, Melissa C.
Clavel, Jacqueline
Virtamo, Jarmo
Weinstein, Stephanie
Riboli, Elio
Vineis, Paolo
Kaaks, Rudolph
Vermeulen, Roel C. H.
Boeing, Heiner
Tjonneland, Anne
Angelucci, Emanuele
Di Lollo, Simonetta
Rais, Marco
Ma, Baoshan
Ye, Yuanqing
Chiu, Brian C. H.
Sampson, Joshua
Park, Ju-Hyun
Chung, Charles C.
Weisenburger, Dennis D.
Chatterjee, Nilanjan
Fraumeni Jr, Joseph F.
Slager, Susan L.
Wu, Xifeng
de Sanjose, Silvia
Smedby, Karin E.
Salles, Gilles
Skibola, Christine F.
Rothman, Nathaniel
Chanock, Stephen J.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ng.3105Metadata
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Cerhan, James R, Sonja I Berndt, Joseph Vijai, Hervé Ghesquières, James McKay, Sophia S Wang, Zhaoming Wang, et al. 2014. “Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Diffuse Large B Cell Lymphoma.” Nature Genetics 46 (11) (September 28): 1233–1238. doi:10.1038/ng.3105.Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of three new genome-wide association studies (GWAS) and one prior scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of nine promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; \(P=2.33x10^{-21}\)), rs2523607 at 6p21.33 (HLA-B; \(2.40x10^{-10}\)), rs79480871 at 2p23.3 (NCOA1; \(P=4.23x10^{-8}\)), and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; \(P=9.98x10^{-13}\) and \(P=3.63x10^{-11}\), respectively). These data provide substantial new evidence for genetic susceptibility to this B-cell malignancy, and point towards pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.Terms of Use
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