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dc.contributor.authorDesai, Nihar R.
dc.contributor.authorKrumme, Alexis A.
dc.contributor.authorSchneeweiss, Sebastian
dc.contributor.authorShrank, William
dc.contributor.authorBrill, Gregory
dc.contributor.authorPezalla, Edmund J.
dc.contributor.authorSpettell, Claire M.
dc.contributor.authorBrennan, Troyen Anthony
dc.contributor.authorMatlin, Olga S.
dc.contributor.authorAvorn, Jerry Lewis
dc.contributor.authorChoudhry, Niteesh Kumar
dc.date.accessioned2018-05-14T14:56:41Z
dc.date.issued2014
dc.identifier.citationDesai, Nihar R., Alexis A. Krumme, Sebastian Schneeweiss, William H. Shrank, Gregory Brill, Edmund J. Pezalla, Claire M. Spettell, et al. 2014. “Patterns of Initiation of Oral Anticoagulants in Patients with Atrial Fibrillation— Quality and Cost Implications.” The American Journal of Medicine 127 (11) (November): 1075–1082.e1. doi:10.1016/j.amjmed.2014.05.013.en_US
dc.identifier.issn0002-9343en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:36880594
dc.description.abstractBackground. Dabigatran, rivaroxaban, and apixaban have been approved for use in patients with atrial fibrillation based upon randomized trials demonstrating their comparable or superior efficacy and safety relative to warfarin. Little is known about their adoption into clinical practice, whether utilization is consistent with the controlled-trials on which their approval was based, and how their use has affected health spending for patients and insurers. Study design. We used medical and prescription claims data from a large insurer to identify patients with non-valvular atrial fibrillation who were prescribed an oral anticoagulant in 2010-2013. We plotted trends in medication initiation over time, assessed corresponding insurer and patient out-of-pocket spending, and evaluated the cumulative number and cost of anticoagulants. We identified predictors of novel anticoagulant initiation using multivariable logistic models. Finally, we estimated the difference in total drug expenditures over 6 months for patients initiating warfarin vs. a novel anticoagulant. Results. 6,893 patients with atrial fibrillation initiated an oral anticoagulant during the study period. By the end of the study period, novel anticoagulants accounted for 62% of new prescriptions and 98% of anticoagulant-related drug costs. Female sex, lower household income and higher \(CHADS_2\), \(CHA_2DS_2-VASC\), and HAS-BLED scores were significantly associated with lower odds of receiving a novel anticoagulant (p<0.001 for each). Average combined patient and insurer anticoagulant spending in the first 6 months after initiation was more than $900 greater for patients initiating a novel anticoagulant. Conclusions. This study demonstrates rapid adoption of novel anticoagulants into clinical practice, particularly among patients with lower \(CHADS_2\) and HAS-BLED scores, and high health care cost consequences. These findings provide important directions for future comparative and cost-effectiveness research.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.amjmed.2014.05.013en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/24859719en_US
dash.licenseOAP
dc.subjectnovel anticoagulanten_US
dc.subjectwarfarinen_US
dc.subjectvitamin K antagonisten_US
dc.subjectFactor Xa inhibitoren_US
dc.subjectpatterns of useen_US
dc.titlePatterns of Initiation of Oral Anticoagulants in Patients with Atrial Fibrillation— Quality and Cost Implicationsen_US
dc.typeJournal Articleen_US
dc.date.updated2014-09-22T13:49:48Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalThe American Journal of Medicineen_US
dash.depositing.authorChoudhry, Niteesh Kumar
dc.date.available2018-05-14T14:56:41Z
dash.affiliation.otherHarvard Medical Schoolen_US
dash.affiliation.otherHarvard School of Public Healthen_US
dc.identifier.doi10.1016/j.amjmed.2014.05.013*
dash.authorsorderedfalse
dash.contributor.affiliatedBrennan, Troyen
dash.contributor.affiliatedShrank, William
dash.contributor.affiliatedChoudhry, Niteesh
dash.contributor.affiliatedAvorn, Jerome
dash.contributor.affiliatedSchneeweiss, Sebastian


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