Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length
View/ Open
Author
Liu, Shixuan
Ginzberg, Miriam Bracha
Patel, Nish
Hild, Marc
Leung, Bosco
Li, Zhengda
Chen, Yen-Chi
Chang, Nancy
Wang, Yuan
Tan, Ceryl
Diena, Shulamit
Trimble, William
Wasserman, Larry
Jenkins, Jeremy L
Kafri, Ran
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.7554/eLife.26947Metadata
Show full item recordCitation
Liu, S., M. B. Ginzberg, N. Patel, M. Hild, B. Leung, Z. Li, Y. Chen, et al. 2017. “Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.” eLife 7 (1): e26947. doi:10.7554/eLife.26947. http://dx.doi.org/10.7554/eLife.26947.Abstract
Animal cells within a tissue typically display a striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown that size uniformity in animal cells is promoted, in part, by size-dependent regulation of G1 length. To identify the molecular mechanisms underlying this process, we performed a large-scale small molecule screen and found that the p38 MAPK pathway is involved in coordinating cell size and cell cycle progression. Small cells display higher p38 activity and spend more time in G1 than larger cells. Inhibition of p38 MAPK leads to loss of the compensatory G1 length extension in small cells, resulting in faster proliferation, smaller cell size and increased size heterogeneity. We propose a model wherein the p38 pathway responds to changes in cell size and regulates G1 exit accordingly, to increase cell size uniformity.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876018/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:37067721
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)