CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells
View/ Open
Author
Kurioka, Ayako
Cosgrove, Cormac
Simoni, Yannick
van Wilgenburg, Bonnie
Geremia, Alessandra
Björkander, Sophia
Sverremark-Ekström, Eva
Thurnheer, Christine
Günthard, Huldrych F.
Khanna, Nina
Aubert, V
Arancibia-Cárcamo, CV
Walker, Lucy Jane
Arancibia-Cárcamo, Carolina V.
Newell, Evan W.
Willberg, Christian B.
Klenerman, Paul
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.3389/fimmu.2018.00486Metadata
Show full item recordCitation
Kurioka, A., C. Cosgrove, Y. Simoni, B. van Wilgenburg, A. Geremia, S. Björkander, E. Sverremark-Ekström, et al. 2018. “CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.” Frontiers in Immunology 9 (1): 486. doi:10.3389/fimmu.2018.00486. http://dx.doi.org/10.3389/fimmu.2018.00486.Abstract
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900032/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:37067880
Collections
- HMS Scholarly Articles [17918]
Contact administrator regarding this item (to report mistakes or request changes)