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dc.contributor.authorLiu, Dajiang J.en_US
dc.contributor.authorPeloso, Gina M.en_US
dc.contributor.authorYu, Haojieen_US
dc.contributor.authorButterworth, Adam S.en_US
dc.contributor.authorWang, Xiaoen_US
dc.contributor.authorMahajan, Anubhaen_US
dc.contributor.authorSaleheen, Danishen_US
dc.contributor.authorEmdin, Connoren_US
dc.contributor.authorAlam, Dewanen_US
dc.contributor.authorAlves, Alexessander Coutoen_US
dc.contributor.authorAmouyel, Philippeen_US
dc.contributor.authordi Angelantonio, Emanueleen_US
dc.contributor.authorArveiler, Dominiqueen_US
dc.contributor.authorAssimes, Themistocles L.en_US
dc.contributor.authorAuer, Paul L.en_US
dc.contributor.authorBaber, Usmanen_US
dc.contributor.authorBallantyne, Christie M.en_US
dc.contributor.authorBang, Lia E.en_US
dc.contributor.authorBenn, Marianneen_US
dc.contributor.authorBis, Joshua C.en_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorBork-Jensen, Jetteen_US
dc.contributor.authorBottinger, Erwin P.en_US
dc.contributor.authorBrandslund, Ivanen_US
dc.contributor.authorBrown, Morrisen_US
dc.contributor.authorBusonero, Fabioen_US
dc.contributor.authorCaulfield, Mark Jen_US
dc.contributor.authorChambers, John Cen_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorChen, Y. Eugeneen_US
dc.contributor.authorChen, Yii-Der Idaen_US
dc.contributor.authorChowdhury, Rajiven_US
dc.contributor.authorChristensen, Crameren_US
dc.contributor.authorChu, Audrey Y.en_US
dc.contributor.authorConnell, John Men_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorCupples, L. Adrienneen_US
dc.contributor.authorDamrauer, Scott M.en_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorDeary, Ian Jen_US
dc.contributor.authorDedoussis, Georgeen_US
dc.contributor.authorDenny, Joshua C.en_US
dc.contributor.authorDominiczak, Annaen_US
dc.contributor.authorDubé, Marie-Pierreen_US
dc.contributor.authorEbeling, Tapanien_US
dc.contributor.authorEiriksdottir, Gudnyen_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorFarmaki, Aliki-Elenien_US
dc.contributor.authorFeitosa, Mary Fen_US
dc.contributor.authorFerrario, Marcoen_US
dc.contributor.authorFerrieres, Jeanen_US
dc.contributor.authorFord, Ianen_US
dc.contributor.authorFornage, Myriamen_US
dc.contributor.authorFranks, Paul W.en_US
dc.contributor.authorFrayling, Timothy M.en_US
dc.contributor.authorFrikke-Schmidt, Ruthen_US
dc.contributor.authorFritsche, Larsen_US
dc.contributor.authorFrossard, Philippeen_US
dc.contributor.authorFuster, Valentinen_US
dc.contributor.authorGanesh, Santhi K.en_US
dc.contributor.authorGao, Weien_US
dc.contributor.authorGarcia, Melissa E.en_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorGiulianini, Francoen_US
dc.contributor.authorGoodarzi, Mark O.en_US
dc.contributor.authorGrallert, Haralden_US
dc.contributor.authorGrarup, Nielsen_US
dc.contributor.authorGroop, Leifen_US
dc.contributor.authorGrove, Megan L.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHirschhorn, Joel N.en_US
dc.contributor.authorHolmen, Oddgeir L.en_US
dc.contributor.authorHuffman, Jenniferen_US
dc.contributor.authorHuo, Yongen_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorJabeen, Sehrishen_US
dc.contributor.authorJackson, Anne Uen_US
dc.contributor.authorJakobsdottir, Johannaen_US
dc.contributor.authorJarvelin, Marjo-Riittaen_US
dc.contributor.authorJensen, Gorm Ben_US
dc.contributor.authorJørgensen, Marit E.en_US
dc.contributor.authorJukema, J. Wouteren_US
dc.contributor.authorJustesen, Johanne M.en_US
dc.contributor.authorKamstrup, Pia R.en_US
dc.contributor.authorKanoni, Stavroulaen_US
dc.contributor.authorKarpe, Fredriken_US
dc.contributor.authorKee, Franken_US
dc.contributor.authorKhera, Amit V.en_US
dc.contributor.authorKlarin, Dereken_US
dc.contributor.authorKoistinen, Heikki A.en_US
dc.contributor.authorKooner, Jaspal Sen_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorKuulasmaa, Karien_US
dc.contributor.authorKuusisto, Johannaen_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorLakka, Timoen_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorLangsted, Anneen_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorLauritzen, Torstenen_US
dc.contributor.authorLiewald, David CMen_US
dc.contributor.authorLin, Li Anen_US
dc.contributor.authorLinneberg, Allanen_US
dc.contributor.authorLoos, Ruth J.F.en_US
dc.contributor.authorLu, Yingchangen_US
dc.contributor.authorLu, Xiangfengen_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorMalarstig, Andersen_US
dc.contributor.authorManichaikul, Anien_US
dc.contributor.authorManning, Alisa K.en_US
dc.contributor.authorMäntyselkä, Pekkaen_US
dc.contributor.authorMarouli, Eirinien_US
dc.contributor.authorMasca, Nicholas GDen_US
dc.contributor.authorMaschio, Andreaen_US
dc.contributor.authorMeigs, James B.en_US
dc.contributor.authorMelander, Olleen_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMorris, Andrew Pen_US
dc.contributor.authorMorrison, Alanna C.en_US
dc.contributor.authorMulas, Antonellaen_US
dc.contributor.authorMüller-Nurasyid, Martinaen_US
dc.contributor.authorMunroe, Patricia B.en_US
dc.contributor.authorNeville, Matt Jen_US
dc.contributor.authorNielsen, Jonas B.en_US
dc.contributor.authorNielsen, Sune Fen_US
dc.contributor.authorNordestgaard, Børge Gen_US
dc.contributor.authorOrdovas, Jose M.en_US
dc.contributor.authorMehran, Roxanaen_US
dc.contributor.authorO’Donnell, Christoper J.en_US
dc.contributor.authorOrho-Melander, Marjuen_US
dc.contributor.authorMolony, Cliona M.en_US
dc.contributor.authorMuntendam, Pieteren_US
dc.contributor.authorPadmanabhan, Sandoshen_US
dc.contributor.authorPalmer, Colin NAen_US
dc.contributor.authorPasko, Dorotaen_US
dc.contributor.authorPatel, Aniruddh P.en_US
dc.contributor.authorPedersen, Olufen_US
dc.contributor.authorPerola, Markusen_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorPisinger, Charlottaen_US
dc.contributor.authorPistis, Giorgioen_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPoulter, Neilen_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorRader, Daniel J.en_US
dc.contributor.authorRasheed, Asifen_US
dc.contributor.authorRauramaa, Raineren_US
dc.contributor.authorReilly, Dermoten_US
dc.contributor.authorReiner, Alex P.en_US
dc.contributor.authorRenström, Fridaen_US
dc.contributor.authorRich, Stephen Sen_US
dc.contributor.authorRidker, Paul Men_US
dc.contributor.authorRioux, John D.en_US
dc.contributor.authorRobertson, Neil Ren_US
dc.contributor.authorRoden, Dan M.en_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorSalomaa, Veikkoen_US
dc.contributor.authorSamani, Nilesh Jen_US
dc.contributor.authorSanna, Serenaen_US
dc.contributor.authorSattar, Naveeden_US
dc.contributor.authorSchmidt, Ellen M.en_US
dc.contributor.authorScott, Robert A.en_US
dc.contributor.authorSever, Peteren_US
dc.contributor.authorSevilla, Raquel S.en_US
dc.contributor.authorShaffer, Christian M.en_US
dc.contributor.authorSim, Xuelingen_US
dc.contributor.authorSivapalaratnam, Sutheshen_US
dc.contributor.authorSmall, Kerrin Sen_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorSmith, Blair Hen_US
dc.contributor.authorSomayajula, Sangeethaen_US
dc.contributor.authorSoutham, Lorraineen_US
dc.contributor.authorSpector, Timothy Den_US
dc.contributor.authorSpeliotes, Elizabeth K.en_US
dc.contributor.authorStarr, John Men_US
dc.contributor.authorStirrups, Kathleen Een_US
dc.contributor.authorStitziel, Nathanen_US
dc.contributor.authorStrauch, Konstantinen_US
dc.contributor.authorStringham, Heather Men_US
dc.contributor.authorSurendran, Praveenen_US
dc.contributor.authorTada, Hayatoen_US
dc.contributor.authorTall, Alan R.en_US
dc.contributor.authorTang, Huaen_US
dc.contributor.authorTardif, Jean-Claudeen_US
dc.contributor.authorTaylor, Kent Den_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorTsao, Philip S.en_US
dc.contributor.authorTuomilehto, Jaakkoen_US
dc.contributor.authorTybjaerg-Hansen, Anneen_US
dc.contributor.authorvan Zuydam, Natalie Ren_US
dc.contributor.authorVarbo, Anetteen_US
dc.contributor.authorVarga, Tibor Ven_US
dc.contributor.authorVirtamo, Jarmoen_US
dc.contributor.authorWaldenberger, Melanieen_US
dc.contributor.authorWang, Nanen_US
dc.contributor.authorWareham, Nick J.en_US
dc.contributor.authorWarren, Helen Ren_US
dc.contributor.authorWeeke, Peter E.en_US
dc.contributor.authorWeinstock, Joshuaen_US
dc.contributor.authorWessel, Jenniferen_US
dc.contributor.authorWilson, James G.en_US
dc.contributor.authorWilson, Peter W. F.en_US
dc.contributor.authorXu, Mingen_US
dc.contributor.authorYaghootkar, Haniehen_US
dc.contributor.authorYoung, Robinen_US
dc.contributor.authorZeggini, Eleftheriaen_US
dc.contributor.authorZhang, Heen_US
dc.contributor.authorZheng, Neil S.en_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorZhang, Yanen_US
dc.contributor.authorZhou, Weien_US
dc.contributor.authorZhou, Yanhuaen_US
dc.contributor.authorZoledziewska, Magdalenaen_US
dc.contributor.authorHowson, Joanna MMen_US
dc.contributor.authorDanesh, Johnen_US
dc.contributor.authorMcCarthy, Mark Ien_US
dc.contributor.authorCowan, Chaden_US
dc.contributor.authorAbecasis, Goncaloen_US
dc.contributor.authorDeloukas, Panosen_US
dc.contributor.authorMusunuru, Kiranen_US
dc.contributor.authorWiller, Cristen J.en_US
dc.contributor.authorKathiresan, Sekaren_US
dc.date.accessioned2018-05-30T17:04:17Z
dc.date.issued2017en_US
dc.identifier.citationLiu, D. J., G. M. Peloso, H. Yu, A. S. Butterworth, X. Wang, A. Mahajan, D. Saleheen, et al. 2017. “Exome-wide association study of plasma lipids in >300,000 individuals.” Nature genetics 49 (12): 1758-1766. doi:10.1038/ng.3977. http://dx.doi.org/10.1038/ng.3977.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37068188
dc.description.abstractWe screened DNA sequence variants on an exome-focused genotyping array in >300,000 participants with replication in >280,000 participants and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice revealed lipid changes consistent with the human data. We utilized mapped variants to address four clinically relevant questions and found the following: (1) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease; (2) outside of the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (3) only some mechanisms of lowering LDL-C seemed to increase risk for type 2 diabetes; and (4) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (e.g., TM6SF2, PNPLA3) tracked with higher liver fat, higher risk for type 2 diabetes, and lower risk for coronary artery disease whereas TG-lowering alleles involved in peripheral lipolysis (e.g., LPL, ANGPTL4) had no effect on liver fat but lowered risks for both type 2 diabetes and coronary artery disease.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.3977en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146/pdf/en
dash.licenseLAAen_US
dc.titleExome-wide association study of plasma lipids in >300,000 individualsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorEmdin, Connoren_US
dc.date.available2018-05-30T17:04:17Z
dc.identifier.doi10.1038/ng.3977*
dash.authorsorderedfalse
dash.contributor.affiliatedEmdin, Connor
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedKhera, Amit
dash.contributor.affiliatedKlarin, Derek
dash.contributor.affiliatedFranks, Paul
dash.contributor.affiliatedPatel, Aniruddh
dash.contributor.affiliatedManning, Alisa
dash.contributor.affiliatedMeigs, James
dash.contributor.affiliatedCowan, Chad


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