Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
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Author
Callas, Peter
McClure, Leslie A.
Unverzagt, Fred
Arora, Garima
Howard, Virginia
Wadley, Virginia G.
Cushman, Mary
Arora, Pankaj
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https://doi.org/10.1016/j.trci.2018.03.006Metadata
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Venkatraman, Anand, Peter Callas, Leslie A. McClure, Fred Unverzagt, Garima Arora, Virginia Howard, Virginia G. Wadley, Mary Cushman, and Pankaj Arora. 2018. “Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites.” Alzheimer's & Dementia : Translational Research & Clinical Interventions 4 (1): 165-172. doi:10.1016/j.trci.2018.03.006. http://dx.doi.org/10.1016/j.trci.2018.03.006.Abstract
Introduction: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. Methods: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. Results: There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1.00 [0.68–1.46], 1.45 [1.01–2.10], and 1.58 [1.10–2.27] relative to the quartile 1; P trend = .003) in an unadjusted model, which persisted after adjusting for age, sex, and race (P = .004). Adjustment for cardiovascular risk factors greatly attenuated this association (odds ratios, 0.97 [0.60–1.57], 1.52 [0.94–2.46], and 1.27 [0.76–2.12]; P = .15). The association differed by diabetes status (P interaction, .007). Among nondiabetics (293 cases, 411 controls), those with galectin-3 in the fourth compared with first quartile had an odds ratio of 1.6 (0.95–2.99; P trend, .02). In diabetics, the odds ratio was 0.23 (0.04–1.33). Discussion Serum galectin-3 was associated with increased risk of incident cognitive impairment in a large cohort study of blacks and whites but only in nondiabetics.Other Sources
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