Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
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Author
Ostrom, Quinn T.
Kinnersley, Ben
Wrensch, Margaret R.
Eckel-Passow, Jeanette E.
Armstrong, Georgina
Rice, Terri
Chen, Yanwen
Wiencke, John K.
McCoy, Lucie S.
Hansen, Helen M.
Amos, Christopher I.
Bernstein, Jonine L.
Il’yasova, Dora
Johansen, Christoffer
Lachance, Daniel H.
Lai, Rose K.
Merrell, Ryan T.
Olson, Sara H.
Sadetzki, Siegal
Schildkraut, Joellen M.
Shete, Sanjay
Rubin, Joshua B.
Lathia, Justin D.
Berens, Michael E.
Andersson, Ulrika
Rajaraman, Preetha
Chanock, Stephen J.
Linet, Martha S.
Wang, Zhaoming
Yeager, Meredith
Beane Freeman, Laura E.
Koutros, Stella
Albanes, Demetrius
Visvanathan, Kala
Stevens, Victoria L.
Henriksson, Roger
Michaud, Dominique S.
Feychting, Maria
Ahlbom, Anders
Giles, Graham G.
Milne, Roger
McKean-Cowdin, Roberta
Le Marchand, Loic
Ruder, Avima M.
Carreon, Tania
Hallmans, Göran
Zeleniuch-Jacquotte, Anne
Purdue, Mark P.
White, Emily
Peters, Ulrike
Houlston, Richard S.
Jenkins, Robert B.
Melin, Beatrice
Bondy, Melissa L.
Barnholtz-Sloan, Jill. S.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/s41598-018-24580-zMetadata
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Ostrom, Q. T., B. Kinnersley, M. R. Wrensch, J. E. Eckel-Passow, G. Armstrong, T. Rice, Y. Chen, et al. 2018. “Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.” Scientific Reports 8 (1): 7352. doi:10.1038/s41598-018-24580-z. http://dx.doi.org/10.1038/s41598-018-24580-z.Abstract
Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943590/pdf/Terms of Use
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