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dc.contributor.authorHallgrımsson, B.
dc.contributor.authorLieberman, Daniel Eric
dc.contributor.authorLiu, W.
dc.contributor.authorFord-Hutchinson, A.F.
dc.contributor.authorJirik, F.R.
dc.date.accessioned2010-03-10T16:42:11Z
dc.date.issued2007
dc.identifier.citationHallgrimssona, B., Daniel E. Liebermanb, W. Liua, A.F. Ford-Hutchinson, and F.R. Jirik. 2007. Epigenetic interactions and the structure of phenotypic variation in the cranium. Evolution and Development 9(1): 76-91.en_US
dc.identifier.issn1520-541Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:3716667
dc.description.abstractUnderstanding the developmental and genetic basis for evolutionarily significant morphological variation in complex phenotypes such as themammalian skull is a challenge because of the sheer complexity of the factors involved. We hypothesize that even in this complex system, the expression of phenotypic variation is structured by the interaction of a few key developmental processes. To test this hypothesis, we created a highly variable sample of crania using four mouse mutants and their wild-type controls from similar genetic backgrounds with developmental perturbations to particular cranial regions. Using geometricmorphometricmethods we compared patterns of size, shape, and integration in the sample within and between the basicranium, neurocranium, and face. The results highlight regular and predictable patterns of covariation among regions of the skull that presumably reflect the epigenetic influences of the genetic perturbations in the sample. Covariation between relative widths of adjoining regions is the most dominant factor, but there are other significant axes of covariation such as the relationship between neurocranial size and basicranial flexion. Although there are other sources of variation related to developmental perturbations not analyzed in this study, the patterns of covariation created by the epigenetic interactions evident in this sample may underlie larger scale evolutionary patterns in mammalian craniofacial form.en_US
dc.description.sponsorshipAnthropologyen_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishingen_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/j.1525-142X.2006.00139.xen_US
dc.relation.isversionofdoi:10.1111/j.1525-142X.2006.00139.xen_US
dc.relation.hasversionhttp://www.fas.harvard.edu/~skeleton/PDFList.html#2007en_US
dash.licenseLAA
dc.titleEpigenetic Interactions and the Structure of Phenotypic Variation in the Craniumen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEvolution and Developmenten_US
dash.depositing.authorLieberman, Daniel Eric
dc.date.available2010-03-10T16:42:11Z
dc.identifier.doi10.1111/j.1525-142X.2006.00139.x*
dash.authorsorderedfalse
dash.contributor.affiliatedLieberman, Daniel
dc.identifier.orcid0000-0002-6194-9127


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