Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor
Gill, Corey M.
Le, Long P.
Chow Maneval, Edna
Ha Paek, Sun
Toyota, Brian D.
Iafrate, A. John
MetadataShow full item record
CitationAlvarez-Breckenridge, C., J. J. Miller, N. Nayyar, C. M. Gill, A. Kaneb, M. D’Andrea, L. P. Le, et al. 2017. “Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.” NPJ Precision Oncology 1 (1): 5. doi:10.1038/s41698-017-0009-y. http://dx.doi.org/10.1038/s41698-017-0009-y.
AbstractGlioneuronal tumors constitute a histologically diverse group of primary central nervous system neoplasms that are typically slow-growing and managed conservatively. Genetic alterations associated with glioneuronal tumors include BRAF mutations and oncogenic fusions. To further characterize this group of tumors, we collected a cohort of 26 glioneuronal tumors and performed in-depth genomic analysis. We identified mutations in BRAF (34%) and oncogenic fusions (30%), consistent with previously published reports. In addition, we discovered novel oncogenic fusions involving members of the NTRK gene family in a subset of our cohort. One-patient with BCAN exon 13 fused to NTRK1 exon 11 initially underwent a subtotal resection for a 4th ventricular glioneuronal tumor but ultimately required additional therapy due to progressive, symptomatic disease. Given the patient’s targetable fusion, the patient was enrolled on a clinical trial with entrectinib, a pan-Trk, ROS1, and ALK (anaplastic lymphoma kinase) inhibitor. The patient was treated for 11 months and during this time volumetric analysis of the lesion demonstrated a maximum reduction of 60% in the contrast-enhancing tumor compared to his pre-treatment magnetic resonance imaging study. The radiologic response was associated with resolution of his clinical symptoms and was maintained for 11 months on treatment. This report of a BCAN-NTRK1 fusion in glioneuronal tumors highlights its clinical importance as a novel, targetable alteration.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37298236
- HMS Scholarly Articles