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dc.contributor.authorAlvarez-Breckenridge, Christopheren_US
dc.contributor.authorMiller, Julie J.en_US
dc.contributor.authorNayyar, Naemaen_US
dc.contributor.authorGill, Corey M.en_US
dc.contributor.authorKaneb, Andrewen_US
dc.contributor.authorD’Andrea, Meganen_US
dc.contributor.authorLe, Long P.en_US
dc.contributor.authorLee, Jesseen_US
dc.contributor.authorCheng, Juen_US
dc.contributor.authorZheng, Zonglien_US
dc.contributor.authorButler, William E.en_US
dc.contributor.authorMultani, Pratiken_US
dc.contributor.authorChow Maneval, Ednaen_US
dc.contributor.authorHa Paek, Sunen_US
dc.contributor.authorToyota, Brian D.en_US
dc.contributor.authorDias-Santagata, Doraen_US
dc.contributor.authorSantagata, Sandroen_US
dc.contributor.authorRomero, Javieren_US
dc.contributor.authorShaw, Alice T.en_US
dc.contributor.authorFarago, Anna F.en_US
dc.contributor.authorYip, Stephenen_US
dc.contributor.authorCahill, Daniel P.en_US
dc.contributor.authorBatchelor, Tracy T.en_US
dc.contributor.authorIafrate, A. Johnen_US
dc.contributor.authorBrastianos, Priscilla K.en_US
dc.date.accessioned2018-07-25T14:21:49Z
dc.date.issued2017en_US
dc.identifier.citationAlvarez-Breckenridge, C., J. J. Miller, N. Nayyar, C. M. Gill, A. Kaneb, M. D’Andrea, L. P. Le, et al. 2017. “Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.” NPJ Precision Oncology 1 (1): 5. doi:10.1038/s41698-017-0009-y. http://dx.doi.org/10.1038/s41698-017-0009-y.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37298236
dc.description.abstractGlioneuronal tumors constitute a histologically diverse group of primary central nervous system neoplasms that are typically slow-growing and managed conservatively. Genetic alterations associated with glioneuronal tumors include BRAF mutations and oncogenic fusions. To further characterize this group of tumors, we collected a cohort of 26 glioneuronal tumors and performed in-depth genomic analysis. We identified mutations in BRAF (34%) and oncogenic fusions (30%), consistent with previously published reports. In addition, we discovered novel oncogenic fusions involving members of the NTRK gene family in a subset of our cohort. One-patient with BCAN exon 13 fused to NTRK1 exon 11 initially underwent a subtotal resection for a 4th ventricular glioneuronal tumor but ultimately required additional therapy due to progressive, symptomatic disease. Given the patient’s targetable fusion, the patient was enrolled on a clinical trial with entrectinib, a pan-Trk, ROS1, and ALK (anaplastic lymphoma kinase) inhibitor. The patient was treated for 11 months and during this time volumetric analysis of the lesion demonstrated a maximum reduction of 60% in the contrast-enhancing tumor compared to his pre-treatment magnetic resonance imaging study. The radiologic response was associated with resolution of his clinical symptoms and was maintained for 11 months on treatment. This report of a BCAN-NTRK1 fusion in glioneuronal tumors highlights its clinical importance as a novel, targetable alteration.en
dc.language.isoen_USen
dc.publisherNature Publishing Group UKen
dc.relation.isversionofdoi:10.1038/s41698-017-0009-yen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871889/pdf/en
dash.licenseLAAen_US
dc.titleClinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumoren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNPJ Precision Oncologyen
dash.depositing.authorAlvarez-Breckenridge, Christopheren_US
dc.date.available2018-07-25T14:21:49Z
dc.identifier.doi10.1038/s41698-017-0009-y*
dash.authorsorderedfalse
dash.contributor.affiliatedButler, William
dash.contributor.affiliatedCheng, Ju
dash.contributor.affiliatedMiller, Julie
dash.contributor.affiliatedAlvarez-Breckenridge, Christopher
dash.contributor.affiliatedFarago, Anna
dash.contributor.affiliatedShaw, Alice
dash.contributor.affiliatedDias-Santagata, Dora
dash.contributor.affiliatedCahill, Daniel
dash.contributor.affiliatedBrastianos, Priscilla
dash.contributor.affiliatedRomero, Javier
dash.contributor.affiliatedBatchelor, Tracy
dash.contributor.affiliatedSantagata, Sandro


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