Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation
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Author
Korzeniewski, Steven J.
Allred, Elizabeth N.
O’Shea, T. Michael
Kuban, Karl C. K.
Lee, Kathleen
McGovern, Anne
Gambardella, Jill
Ursprung, Susan
Ecklund, Ruth Blomquist Kristen
Bassan, Haim
Butler, Samantha
Duplessis, Adré
Hahn, Cecil
Limperopoulos, Catherine
Khwaja, Omar
Soul, Janet S.
Shah, Bhavesh
Christianson, Karen
Hampf, Frederick
Gilmore, Herbert
McQuiston, Susan
Hallisey, Colleen
Hurley, Caitlin
Creixell, Miren
Share, Jane
Insoft, Robert M.
Wilson, Jennifer G.
Pimental, Maureen
Cole, Cynthia
Fiascone, John M.
Madden, Janet
Nylen, Ellen
McCauley, Anne Furey Roy
Church, Paige T.
Keller, Cecelia
Miller, Karen J.
Bednarek, Francis
Naples, Mary
Powers, Beth
Wellman, Jacqueline
Adair, Robin
Bream, Richard
Miller, Alice
Scheiner, Albert
Stine, Christy
Ehrenkranz, Richard
Williams, Joanne
Romano, Elaine
Miller, Cindy
Close, Nancy
Gordon, Debbie
Harold, Teresa
Specter, Barbara
Allred, Deborah
Dillard, Robert
Goldstein, Don
Hiatt, Deborah
Hounshell, Gail
Waldrep, Ellen
Washburn, Lisa
Welch, Cherrie D.
Engelke, Stephen C.
Moseley, Sherry
Pare, Linda
Smart, Donna
Wilson, Joan
Adler, Ira
Buckwald, Sharon
Helms, Rebecca
Kerkering, Kathyrn
MacGilvray, Scott S.
Resnik, Peter
Bose, Carl
Bose, Gennie
Fordham, Lynn A.
Bostic, Lisa
Marshall, Diane
Milowic, Kristi
Wereszczak, Janice
Poortenga, Mariel
Sutton, Dinah
Betz, Bradford W.
Bezinque, Steven L.
Junewick, Joseph
Burdo-Hartman, Wendy
Fagerman, Lynn
Lohr, Kim
Pastyrnak, Steve
Solomon, Carolyn
Cavenagh, Ellen
Caine, Victoria J.
Olomu, Nicholas
Price, Joan
Paneth, Nigel
Karna, Padmani
Lenski, Madeleine
Schreiber, Michael D.
Yoon, Grace
Feinstein, Kate
Caldarelli, Leslie
O’Connor, Sunila E.
Msall, Michael
Plesha-Troyke, Susan
Batton, Daniel
Kring, Beth
Brooklier, Karen
Oca, Melisa J.
Solomon, Katherine M.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/s41398-018-0156-0Metadata
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Korzeniewski, S. J., E. N. Allred, T. M. O’Shea, A. Leviton, K. C. K. Kuban, K. Lee, A. McGovern, et al. 2018. “Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation.” Translational Psychiatry 8 (1): 115. doi:10.1038/s41398-018-0156-0. http://dx.doi.org/10.1038/s41398-018-0156-0.Abstract
Among the 1 of 10 children who are born preterm annually in the United States, 6% are born before the third trimester. Among children who survive birth before the 28th week of gestation, the risks of autism spectrum disorder (ASD) and non-autistic social impairment are severalfold higher than in the general population. We examined the relationship between top quartile inflammation-related protein concentrations among children born extremely preterm and ASD or, separately, a high score on the Social Responsiveness Scale (SRS total score ≥65) among those who did not meet ASD criteria, using information only from the subset of children whose DAS-II verbal or non-verbal IQ was ≥70, who were assessed for ASD, and who had proteins measured in blood collected on ≥2 days (N = 763). ASD (N = 36) assessed at age 10 years is associated with recurrent top quartile concentrations of inflammation-related proteins during the first post-natal month (e.g., SAA odds ratio (OR); 95% confidence interval (CI): 2.5; 1.2–5.3) and IL-6 (OR; 95% CI: 2.6; 1.03–6.4)). Top quartile concentrations of neurotrophic proteins appear to moderate the increased risk of ASD associated with repeated top quartile concentrations of inflammation-related proteins. High (top quartile) concentrations of SAA are associated with elevated risk of ASD (2.8; 1.2–6.7) when Ang-1 concentrations are below the top quartile, but not when Ang-1 concentrations are high (1.3; 0.3–5.8). Similarly, high concentrations of TNF-α are associated with heightened risk of SRS-defined social impairment (N = 130) (2.0; 1.1–3.8) when ANG-1 concentrations are not high, but not when ANG-1 concentrations are elevated (0.5; 0.1–4.2).Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993745/pdf/Terms of Use
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