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dc.contributor.authorAkhter, Murtazaen_US
dc.contributor.authorQin, Tomen_US
dc.contributor.authorFischer, Paulen_US
dc.contributor.authorSadeghian, Homaen_US
dc.contributor.authorKim, Hyung Hwanen_US
dc.contributor.authorWhalen, Michael J.en_US
dc.contributor.authorGoldstein, Joshua N.en_US
dc.contributor.authorAyata, Cenken_US
dc.date.accessioned2018-07-25T14:22:25Z
dc.date.issued2018en_US
dc.identifier.citationAkhter, Murtaza, Tom Qin, Paul Fischer, Homa Sadeghian, Hyung Hwan Kim, Michael J. Whalen, Joshua N. Goldstein, and Cenk Ayata. 2018. “Rho‐kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage.” Annals of Clinical and Translational Neurology 5 (6): 769-776. doi:10.1002/acn3.569. http://dx.doi.org/10.1002/acn3.569.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37298300
dc.description.abstractAbstract Rho‐associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre‐hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform‐nonselective inhibitor fasudil, or ROCK2‐selective inhibitor KD025, or their vehicles. In the ICH model, treatments were administered 1 h after collagenase injection. Although KD025 but not fasudil prolonged the tail bleeding times, neither drug expanded the volume of ICH or worsened neurological deficits at 48 h compared with vehicle. Although more testing is needed in aged animals and comorbid models such as diabetes, these results suggest ROCK inhibitors may be safe for pre‐hospital administration in acute stroke.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1002/acn3.569en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989779/pdf/en
dash.licenseLAAen_US
dc.subjectBrief Communicationen
dc.titleRho‐kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhageen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAnnals of Clinical and Translational Neurologyen
dash.depositing.authorFischer, Paulen_US
dc.date.available2018-07-25T14:22:25Z
dc.identifier.doi10.1002/acn3.569*
dash.contributor.affiliatedFischer, Paul
dash.contributor.affiliatedSadeghian, Homa
dash.contributor.affiliatedWhalen, Michael
dash.contributor.affiliatedGoldstein, Joshua
dash.contributor.affiliatedAyata, Cenk


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