dc.contributor.author | Sanders, Samantha | |
dc.date.accessioned | 2020-09-15T14:46:26Z | |
dash.embargo.terms | 2021-05-01 | |
dc.date.created | 2020-05 | |
dc.date.issued | 2020-06-24 | |
dc.date.submitted | 2020 | |
dc.identifier.citation | Sanders, Samantha. 2020. Self-Reported Allergies in IgG4-Related Disease: A Case-Control Study. Doctoral dissertation, Harvard Medical School. | |
dc.identifier.uri | https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365199 | * |
dc.description.abstract | Objective: IgG4-related disease (IgG4-RD) is an immune-mediated condition of unknown etiology. There has been controversy over the significance of allergic conditions in IgG4-RD. We examined the prevalence of allergy symptoms in IgG4-RD and the association between allergy symptoms and IgG4-RD in a case-control study.
Methods: We identified IgG4-RD patients and non-IgG4-RD controls seen at a single center. IgG4-RD patients were classified using the ACR/EULAR classification criteria. Allergy symptoms were ascertained by questionnaire. We assessed the association of IgG4-RD features (e.g., age of onset, organ involvement) with self-reported allergy symptoms. We compared the proportion of cases and controls with allergic symptoms using conditional logistic regression to estimate odds ratios and 95% confidence intervals after matching cases and controls 1:1 by age and sex.
Results: Allergic symptoms were reported by 165 (71%) of 231 IgG4-RD cases who completed the questionnaire. Compared to those without allergies, IgG4-RD cases with allergies were more likely to have head and neck involvement (adjusted odds ratio 2.0 [95% CI: 1.1-3.6]) and more likely to have peripheral eosinophilia (adjusted odds ratio 3.3 [95% CI: 1.2-9.0]). The prevalence of allergic symptoms among IgG4-RD cases was not different from that of the controls with other rheumatic conditions (110 [72%] vs. 114 [75%], OR 0.9 [95% CI: 0.5-1.5]).
Discussion: Allergic symptoms are common in IgG4-RD but are reported with a similar frequency by patients with IgG4-RD and patients with other rheumatic conditions. These findings suggest that allergic conditions are not uniquely linked to the pathogenesis of IgG4-RD. | |
dc.description.sponsorship | Honors in a Special Field | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dash.license | LAA | |
dc.subject | IgG4-Related Disease | |
dc.subject | allergies | |
dc.title | Self-Reported Allergies in IgG4-Related Disease: A Case-Control Study | |
dc.type | Thesis or Dissertation | |
dash.depositing.author | Sanders, Samantha | |
dash.embargo.until | 2021-05-01 | |
dc.date.available | 2020-09-15T14:46:26Z | |
thesis.degree.date | 2020 | |
thesis.degree.grantor | Harvard Medical School | |
thesis.degree.grantor | Harvard Medical School | |
thesis.degree.level | Doctoral | |
thesis.degree.level | Doctoral | |
thesis.degree.name | Doctor of Medicine | |
thesis.degree.name | Doctor of Medicine | |
dc.type.material | text | |
dash.identifier.vireo | | |
dash.author.email | samanthafarasanders@gmail.com | |