dc.contributor.author | Kissler, Stephen | |
dc.contributor.author | Fauver, Joseph R. | |
dc.contributor.author | Mack, Christina | |
dc.contributor.author | Tai, Caroline G. | |
dc.contributor.author | Breban, Mallery I. | |
dc.contributor.author | Watkins, Anne E. | |
dc.contributor.author | Samant, Radhika M. | |
dc.contributor.author | Anderson, Deverick J. | |
dc.contributor.author | Ho, David D. | |
dc.contributor.author | Grubaugh, Nathan D. | |
dc.contributor.author | Grad, Yonatan | |
dc.date.accessioned | 2021-02-16T16:07:32Z | |
dc.date.issued | 2021-02-16 | |
dc.identifier.citation | Kissler, Stephen, Joseph R. Fauver, Christina Mack, Caroline G. Tai, Mallery I. Breban, et al. "Densely sampled viral trajectories suggest longer duration of acute infection with B.1.1.7 variant relative to non-B.1.1.7 SARS-CoV-2." Preprint, 2021. | en_US |
dc.identifier.uri | https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37366884 | * |
dc.description.abstract | To test whether acute infection with B.1.1.7 is associated with higher or more sustained nasopharyngeal viral concentrations, we assessed longitudinal PCR tests performed in a cohort of 65 individuals infected with SARS-CoV-2 undergoing daily surveillance testing, including seven in fected with B.1.1.7. For individuals infected with B.1.1.7, the mean duration of the proliferation phase was 5.3 days (90% credible interval [2.7, 7.8]), the mean duration of the clearance phase was 8.0 days [6.1, 9.9], and the mean overall duration of infection (proliferation plus clearance) was 13.3 days [10.1, 16.5]. These compare to a mean proliferation phase of 2.0 days [0.7, 3.3], a mean clearance phase of 6.2 days [5.1, 7.1], and a mean duration of infection of 8.2 days [6.5, 9.7] for non-B.1.1.7 virus. The peak viral concentration for B.1.1.7 was 19.0 Ct [15.8, 22.0] compared to 20.2 Ct [19.0, 21.4] for non-B.1.1.7. This converts to 8.5 log10 RNA copies/ml [7.6, 9.4] for B.1.1.7 and 8.2 log10 RNA copies/ml [7.8, 8.5] for non-B.1.1.7. These data offer evidence that SARS-CoV-2 variant B.1.1.7 may cause longer infections with similar peak viral concentration compared to non-B.1.1.7 SARS-CoV-2. This extended duration may contribute to B.1.1.7 SARS CoV-2’s increased transmissibility. | en_US |
dc.language.iso | en_US | en_US |
dash.license | LAA | |
dc.title | Densely sampled viral trajectories suggest longer duration of acute infection with B.1.1.7 variant relative to non-B.1.1.7 SARS-CoV-2 | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Author's Original | en_US |
dash.depositing.author | Grad, Yonatan | |
dc.date.available | 2021-02-16T16:07:32Z | |
dash.affiliation.other | Harvard T.H. Chan School of Public Health | en_US |
dash.contributor.affiliated | Grad, Yonatan | |
dash.contributor.affiliated | Kissler, Stephen | |