Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP
Bhatt, Rupal S.
Sukhatme, Vikas P.
Lenkinski, Robert E.
Grant, Aaron K.
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CitationRobson PM, Madhuranthakam AJ, Smith MP, Sun MR, Dai W, Rofsky NM, Pedrosa I, Alsop DC. 2016. Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition. Academic Radiology 23, no. 2:144-54. PMID: 26521186.
AbstractPurpose—In balanced steady state free precession (bSSFP), the signal intensity has a wellknown dependence on the off-resonance frequency, or, equivalently, the phase advance between successive radiofrequency (RF) pulses. The signal profile can be used to resolve the contributions from the spectrally separated metabolites. This work describes a method based on use of a variable RF phase advance to acquire spatial and spectral data in a time-efficient manner for hyperpolarized 13C MRI.
Theory and Methods—The technique relies on the frequency response from a bSSFP acquisition to acquire relatively rapid, high-resolution images that may be reconstructed to separate contributions from different metabolites. The ability to produce images from spectrally separated metabolites was demonstrated in-vitro, as well as in-vivo following administration of hyperpolarized 1-13C pyruvate in mice with xenograft tumors.
Results—In-vivo images of pyruvate, alanine, pyruvate hydrate and lactate were reconstructed from 4 images acquired in 2 seconds with an in-plane resolution of 1.25 × 1.25mm2 and 5mm slice thickness.
Conclusions—The phase advance method allowed acquisition of spectroscopically selective images with high spatial and temporal resolution. This method provides an alternative approach to hyperpolarized 13C spectroscopic MRI that can be combined with other techniques such as multiecho or fluctuating equilibrium bSSFP.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367085
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