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dc.contributor.authorChen, Zhao
dc.contributor.authorFillmore, Christine M.
dc.contributor.authorHammerman, Peter S.
dc.contributor.authorKim, Carla
dc.contributor.authorWong, Kwok-Kin
dc.contributor.authorChen, Zhao
dc.date.accessioned2021-04-06T15:20:53Z
dc.date.issued2014-07-24
dc.identifier.citationChen, Zhao, Christine M. Fillmore, Peter S. Hammerman, Carla F. Kim, and Kwok-Kin Wong. 2014. "Non-small-cell lung cancers: a heterogeneous set of diseases." Nature Reviews Cancer 14, no. 8: 535-546.en_US
dc.identifier.issn1474-175Xen_US
dc.identifier.issn1474-1768en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367173*
dc.description.abstractNon-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have diverse pathological features. During the past decade, in-depth analyses of lung cancer genomes and signalling pathways have further defined NSCLCs as a group of distinct diseases with genetic and cellular heterogeneity. Consequently, an impressive list of potential therapeutic targets was unveiled, drastically altering the clinical evaluation and treatment of patients. Many targeted therapies have been developed with compelling clinical proofs of concept; however, treatment responses are typically short-lived. Further studies of the tumour microenvironment have uncovered new possible avenues to control this deadly disease, including immunotherapy.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dash.licenseLAA
dc.subjectCancer Researchen_US
dc.subjectOncologyen_US
dc.titleNon-Small-Cell Lung Cancers: A Heterogeneous Set of Diseasesen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNature Reviews Canceren_US
dc.date.available2021-04-06T15:20:53Z
dc.identifier.doi10.1038/nrc3775
dc.source.journalNat Rev Cancer
dash.source.volume14;8en_US
dash.source.page535-546en_US
dash.contributor.affiliatedKim, Carla


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