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dc.contributor.authorLi, Yong
dc.contributor.authorMatsui, Jonathan I.
dc.contributor.authorDowling, John E.
dc.date.accessioned2021-04-26T16:41:41Z
dc.date.issued2009
dc.identifier.citationLi, Yong N., Jonathan. I. Matsui, and John E. Dowling. 2009. Specificity of the horizontal cell-photoreceptor connections in the zebrafish (danio rerio) retina. Journal of Comparative Neurology 516(5): 442-453.en_US
dc.identifier.issn0021-9967en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367400*
dc.description.abstractHorizontal cells (HCs) are involved in establishing the center-surround receptive field organization of photoreceptor and bipolar cells. In many species, HCs respond differentially to colors and may play a role in color vision. An earlier study from our laboratory suggested that four types of HCs exist in the zebrafish retina: three cone HCs (H1, H2 and H3) and one rod HC. In this study, we describe their photoreceptor connections. Cones are arranged in a mosaic in which rows of alternating blue (B)- and ultraviolet (UV)-sensitive single cones alternate with rows of red (R)- and green (G)-sensitive double cones; the G cones are adjacent to UV cones and B cones adjacent to R cones. Two small-field (H1 and H2) and two large-field (H3 and rod HC) cells were observed. The cone HC dendritic terminals connected to cones with single boutons, doublets, or rosettes, whereas the rod HCs connected to rods with single boutons. The single boutons/doublets/rosettes of cone HCs were arranged in double rows separated by single rows for H1 cells, in pairs and singles for H2 cells, and in a rectilinear pattern for H3 cells. These connectivity patterns suggest that H1 cells contact R, G, and B cones, H2 cells G, B, and UV cones, and H3 cells B and UV cones. These predictions were confirmed by applying the DiI method to SWS1-GFP retinas whose UV cones express green fluorescent protein. Each rod HC was adjacent to the soma or axon of a DiI-labeled cone HC and connected to 50-200 rods.en_US
dc.description.sponsorshipMolecular and Cellular Biologyen_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1002/cne.22135en_US
dash.licenseMETA_ONLY
dc.subjectDiIen_US
dc.subjectphotoreceptorsen_US
dc.subjecthorizontal cellsen_US
dc.subjectretinaen_US
dc.subjectconnectivityen_US
dc.subjectzebrafishen_US
dc.titleSpecificity of the Horizontal Cell-PhotoreceptorConnections in the Zebrafish (Danio Rerio) Retinaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Comparative Neurologyen_US
dash.depositing.authorDowling, John E.
dc.date.available2021-04-26T16:41:41Z
dc.identifier.doi10.1002/cne.22135*
dash.contributor.affiliatedLi, Yong
dash.contributor.affiliatedDowling, John


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