dc.contributor.author | Metsky, Hayden C | |
dc.contributor.author | Matranga, Christian B | |
dc.contributor.author | Wohl, Shirlee | |
dc.contributor.author | Schaffner, Stephen | |
dc.contributor.author | Freije, Catherine Amanda | |
dc.contributor.author | Winnicki, Sarah M. | |
dc.contributor.author | West, Kendra Leigh | |
dc.contributor.author | Qu, James | |
dc.contributor.author | Baniecki, Mary | |
dc.contributor.author | Gladden-Young, Adrianne | |
dc.contributor.author | Lin, Aaron Eric | |
dc.contributor.author | Tomkins-Tinch, Christopher Holiday | |
dc.contributor.author | Ye, Simon H | |
dc.contributor.author | Park, Daniel Sangsoon | |
dc.contributor.author | Luo, Cynthia | |
dc.contributor.author | Barnes, Kayla G. | |
dc.contributor.author | Shah, Rickey | |
dc.contributor.author | Chak, Bridget | |
dc.contributor.author | Barbosa-Lima, Giselle | |
dc.contributor.author | Delatorre, Edson | |
dc.contributor.author | Vieira, Yasmine R | |
dc.contributor.author | Paul, Lauren M | |
dc.contributor.author | Tan, Amanda L | |
dc.contributor.author | Barcellona, Carolyn M | |
dc.contributor.author | Porcelli, Mario C | |
dc.contributor.author | Vasquez, Chalmers | |
dc.contributor.author | Cannons, Andrew C | |
dc.contributor.author | Cone, Marshall R | |
dc.contributor.author | Hogan, Kelly N | |
dc.contributor.author | Kopp, Edgar W | |
dc.contributor.author | Anzinger, Joshua J | |
dc.contributor.author | Garcia, Kimberly F | |
dc.contributor.author | Parham, Leda A | |
dc.contributor.author | Gelvez Ramirez, Rosa Margarita | |
dc.contributor.author | Miranda Montoya, Maria Consuelo | |
dc.contributor.author | Rojas, Diana P | |
dc.contributor.author | Brown, Catherine M | |
dc.contributor.author | Hennigan, Scott | |
dc.contributor.author | Sabina, Brandon | |
dc.contributor.author | Scotland, Sarah | |
dc.contributor.author | Gangavarapu, Karthik | |
dc.contributor.author | Grubaugh, Nathan D | |
dc.contributor.author | Oliveira, Glenn | |
dc.contributor.author | Robles-Sikisaka, Refugio | |
dc.contributor.author | Rambaut, Andrew | |
dc.contributor.author | Gehrke, Lee | |
dc.contributor.author | Smole, Sandra | |
dc.contributor.author | Halloran, M Elizabeth | |
dc.contributor.author | Villar Centeno, Luis Angel | |
dc.contributor.author | Mattar, Salim | |
dc.contributor.author | Lorenzana, Ivette | |
dc.contributor.author | Cerbino-Neto, Jose | |
dc.contributor.author | Valim, Clarissa | |
dc.contributor.author | Degrave, Wim | |
dc.contributor.author | Bozza, Patricia T | |
dc.contributor.author | Gnirke, Andreas | |
dc.contributor.author | Andersen, Kristian G | |
dc.contributor.author | Isern, Sharon | |
dc.contributor.author | Michael, Scott | |
dc.contributor.author | Bozza, Fernando A | |
dc.contributor.author | Souza, Thiago ML | |
dc.contributor.author | Bosch, Irene | |
dc.contributor.author | Yozwiak, Nathan L | |
dc.contributor.author | MacInnis, Bronwyn L | |
dc.contributor.author | Sabeti, Pardis Christine | |
dc.date.accessioned | 2021-05-26T16:46:50Z | |
dc.date.issued | 2017 | |
dc.identifier | Quick submit: 2017-04-26T11:12:11-0400 | |
dc.identifier.citation | Metsky, Hayden C, Christian B. Matranga, Shirlee Wohl, Stephen Schaffner, Catherine Freije, et al. 2017. "Zika virus evolution and spread in the Americas." Nature 546: 411–415. doi: 10.1038/nature22402. | en_US |
dc.identifier.uri | https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367721 | * |
dc.description.abstract | Despite great attention given to the recent Zika virus (ZIKV) epidemic in the Americas, much remains unknown about its epidemiology and evolution, in part due to a lack of genomic data. We applied multiple sequencing approaches to generate 100 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analyzed the timing and patterns of introductions into distinct geographic regions, confirming phylogenetic evidence for the origin and rapid expansion of the outbreak in Brazil, and for multiple introductions from Brazil into Honduras, Colombia, Puerto Rico, other Caribbean islands, and the continental US. We find that ZIKV circulated undetected in many regions of the Americas for up to a year before the first locally transmitted cases were confirmed, highlighting the challenge of effective surveillance for this virus. We further characterize genetic variation across the outbreak to identify mutations with possible functional implications for ZIKV biology and pathogenesis. | en_US |
dc.description.sponsorship | Molecular and Cellular Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SpringerNature | en_US |
dc.relation.isversionof | 10.1038/nature22402 | en_US |
dc.relation.hasversion | http://biorxiv.org/content/biorxiv/early/2017/04/23/109348.full.pdf | en_US |
dash.license | LAA | |
dc.subject | Zika | en_US |
dc.title | Zika virus evolution and spread in the Americas | en_US |
dc.type | Journal Article | en_US |
dc.date.updated | 2017-04-26T15:12:21Z | |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Nature | en_US |
dash.depositing.author | Gehrke, Lee | |
dash.waiver | 2017-04-26 | |
dc.date.available | 2017 | |
dc.date.available | 2021-05-26T16:46:50Z | |
dash.affiliation.other | Broad Institute of MIT and Harvard | en_US |
dash.affiliation.other | Extension School | en_US |
dash.affiliation.other | Microbiology and Immunobiology, HMS | en_US |
dc.identifier.doi | 10.1101/109348 | * |
dash.source.volume | 546 | en_US |
dash.source.page | 411–415 | en_US |
dash.contributor.affiliated | Tomkins-Tinch, Christopher | |
dash.contributor.affiliated | Lin, Aaron | |
dash.contributor.affiliated | Park, Daniel | |
dash.contributor.affiliated | Luo, Cynthia | |
dash.contributor.affiliated | Baniecki, Mary | |
dash.contributor.affiliated | Shah, Rickey | |
dash.contributor.affiliated | Schaffner, Stephen | |
dash.contributor.affiliated | West, Kendra L. | |
dash.contributor.affiliated | Winnicki, Sarah | |
dash.contributor.affiliated | Wohl, Shirlee | |
dash.contributor.affiliated | Barnes, Kayle | |
dash.contributor.affiliated | Freije, Catherine | |
dash.contributor.affiliated | Gehrke, Lee | |
dash.contributor.affiliated | Chak, Bridget | |
dash.contributor.affiliated | Sabeti, Pardis | |