The Atg1-Tor Pathway Regulates Yolk Catabolism in Drosophila Embryos
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https://doi.org/10.1242/dev.125419Metadata
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Kuhn, Hallie, Richelle Sopko, Margaret Coughlin, Norbert Perrimon, Timothy Mitchison. "The Atg1-Tor Pathway Regulates Yolk Catabolism in Drosophila Embryos." Development 142, no. 22 (2015): 3869-3878. DOI: 10.1242/dev.125419Abstract
Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712880/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368107
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