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dc.contributor.authorKuhn, Hallie
dc.contributor.authorSopko, Richelle
dc.contributor.authorCoughlin, Margaret
dc.contributor.authorPerrimon, Norbert
dc.contributor.authorMitchison, Timothy
dc.date.accessioned2021-07-06T13:59:27Z
dc.date.issued2015-11-15
dc.identifier.citationKuhn, Hallie, Richelle Sopko, Margaret Coughlin, Norbert Perrimon, Timothy Mitchison. "The Atg1-Tor Pathway Regulates Yolk Catabolism in Drosophila Embryos." Development 142, no. 22 (2015): 3869-3878. DOI: 10.1242/dev.125419
dc.identifier.issn0950-1991en_US
dc.identifier.issn1477-9129en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368107*
dc.description.abstractYolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome.en_US
dc.language.isoen_USen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.isversionofdoi:10.1242/dev.125419en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712880/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biologyen_US
dc.titleThe Atg1-Tor Pathway Regulates Yolk Catabolism in Drosophila Embryosen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDevelopmenten_US
dash.depositing.authorPerrimon, Norbert
dc.date.available2021-07-06T13:59:27Z
dc.identifier.doi10.1242/dev.125419
dc.source.journalDevelopment
dash.source.volume142en_US
dash.source.page3869-3878en_US
dash.source.issue22en_US
dash.contributor.affiliatedCoughlin, Margaret
dash.contributor.affiliatedMitchison, Timothy
dash.contributor.affiliatedPerrimon, Norbert


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