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dc.contributor.advisorKreiman, Gabriel
dc.contributor.authorWang, Jiarui
dc.date.accessioned2021-07-13T04:27:46Z
dc.date.created2021
dc.date.issued2021-04-29
dc.date.submitted2021-05
dc.identifier.citationWang, Jiarui. 2021. Mesoscopic physiological interactions in the human brain reveal small-world properties and associations with behavior. Doctoral dissertation, Harvard University Graduate School of Arts and Sciences.
dc.identifier.other28492144
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368218*
dc.description.abstractCognition depends on rapid and robust communication between neural circuits spanning different brain areas. Here we investigated the mesoscopic network of cortico-cortical interactions in the human brain in an extensive dataset consisting of 6,024 hours of intracranial field potential recordings from 4,142 electrodes in 48 subjects. Communication between brain areas was evaluated in a pairwise fashion and at the network level across different frequency bands. The interaction networks were validated against known anatomical measurements and neurophysiological interactions in humans and monkeys. The resulting human brain interactome is characterized by a broad and spatially specific, dynamic, and extensive. The physiological interactome revealed small-world properties, which we conjecture might facilitate efficient and reliable information transmission. The interaction dynamics correlate with the brain sleep/awake and also with natural behaviors. These results constitute initial steps towards understanding how the interactome orchestrates cortical communication and provide a reference for future efforts to assess how dysfunctional interactions may lead to mental disorders.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dash.licenseLAA
dc.subjectFunctional connectomics
dc.subjectGraph theory
dc.subjectHuman Neurophysiology
dc.subjectLarge-scale brain organization
dc.subjectNeural interactions
dc.subjectSleep
dc.subjectNeurosciences
dc.subjectBioinformatics
dc.subjectBiostatistics
dc.titleMesoscopic physiological interactions in the human brain reveal small-world properties and associations with behavior
dc.typeThesis or Dissertation
dash.depositing.authorWang, Jiarui
dc.date.available2021-07-13T04:27:46Z
thesis.degree.date2021
thesis.degree.grantorHarvard University Graduate School of Arts and Sciences
thesis.degree.levelDoctoral
thesis.degree.namePh.D.
dc.contributor.committeeMemberBuckner, Randy L
dc.contributor.committeeMemberDrugowitsch, Jan
dc.contributor.committeeMemberLivingstone, Margaret S
dc.contributor.committeeMemberKennedy, Henry
dc.type.materialtext
thesis.degree.departmentMedical Sciences
dc.identifier.orcid0000-0003-0301-5016
dash.author.emailmr.jiarui.wang@gmail.com


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