Functional circuit architecture underlying parental behaviour
Author
Kohl, Johannes
Babayan, Benedicte M.
Rubinstein, Nimrod D.
Marin-Rodriguez, Brenda
Miyamishi, Kazunari
Zweifel, Larry S.
Luo, Liqun
Published Version
https://doi.org/10.1038/s41586-018-0027-0Metadata
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Kohl, Johannes, Benedicte M. Babayan, Nimrod D. Rubinstein, Anita Autry, Brenda Marin-Rodriguez, Vikrant Kapoor, Kazunari Miyamishi et al. "Functional circuit architecture underlying parental behaviour." Nature 556, no. 7701 (2018): 326-331. DOI: 10.1038/s41586-018-0027-0Abstract
Parenting is essential for the survival and wellbeing of mammalian offspring but we lack a circuit-level understanding of how distinct components of this behaviour are orchestrated. Here we investigate how Galanin-expressing neurons in the medial preoptic area (MPOAGal) coordinate motor, motivational, hormonal and social aspects of parenting. These neurons integrate inputs from a large number of brain areas, whose activation depends on the animal’s sex and reproductive state. Subsets of MPOAGal neurons form discrete pools defined by their projection sites. While the MPOAGal population is active during all episodes of parental behaviour, individual pools are tuned to characteristic aspects of parenting. Optogenetic manipulation of MPOAGal projections mirrors this specificity, affecting discrete parenting components. This functional organization, reminiscent of the control of motor sequences by pools of spinal cord neurons, provides a new model for how discrete elements of a social behaviour are generated at the circuit level.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908752/Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368614
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