Histone variants and cellular plasticity
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https://doi.org/10.1016/j.tig.2015.07.005Metadata
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Santoro, Stephen W, Catherine Dulac. "Histone variants and cellular plasticity." Trends in Genetics 31, no. 9 (2015): 516-527. DOI: 10.1016/j.tig.2015.07.005Abstract
The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is chromatin, a dynamic nucleoprotein complex that helps mediate gene regulation. The most basic subunit of chromatin, the nucleosome, consists of DNA wrapped around histones, a set of proteins that play critical roles as scaffolding molecules and regulators of gene expression. Growing evidence indicates that canonical histones are commonly replaced by protein variants prior to and during cellular transitions. Here we highlight exciting new results suggesting that histone variants are essential players in the control of cellular plasticity during development and in the adult nervous system.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111554/Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368686
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