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dc.contributor.authorSantoro, Stephen W
dc.contributor.authorDulac, Catherine
dc.date.accessioned2021-07-22T11:05:58Z
dc.date.issued2015-09
dc.identifier.citationSantoro, Stephen W, Catherine Dulac. "Histone variants and cellular plasticity." Trends in Genetics 31, no. 9 (2015): 516-527. DOI: 10.1016/j.tig.2015.07.005
dc.identifier.issn0168-9525en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368686*
dc.description.abstractThe broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is chromatin, a dynamic nucleoprotein complex that helps mediate gene regulation. The most basic subunit of chromatin, the nucleosome, consists of DNA wrapped around histones, a set of proteins that play critical roles as scaffolding molecules and regulators of gene expression. Growing evidence indicates that canonical histones are commonly replaced by protein variants prior to and during cellular transitions. Here we highlight exciting new results suggesting that histone variants are essential players in the control of cellular plasticity during development and in the adult nervous system.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.tig.2015.07.005en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111554/en_US
dash.licenseOAP
dc.subjectGeneticsen_US
dc.titleHistone variants and cellular plasticityen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalTrends in Geneticsen_US
dash.depositing.authorDulac, Catherine
dc.date.available2021-07-22T11:05:58Z
dc.identifier.doi10.1016/j.tig.2015.07.005
dc.source.journalTrends in Genetics
dash.source.volume31en_US
dash.source.page516-527en_US
dash.source.issue9en_US
dash.contributor.affiliatedDulac, Catherine


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