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dc.contributor.authorRacine, Annie M.
dc.contributor.authorFong, Tamara
dc.contributor.authorTravison, Thomas
dc.contributor.authorJones, Richard N.
dc.contributor.authorGou, Yun
dc.contributor.authorVasunilashorn, Sarinnapha
dc.contributor.authorMarcantonio, Edward
dc.contributor.authorAlsop, David
dc.contributor.authorInouye, Sharon
dc.contributor.authorDickerson, Bradford
dc.date.accessioned2021-08-30T14:48:30Z
dc.date.issued2017-11
dc.identifier.citationRacine, Annie M., Tamara G. Fong, Thomas G. Travison, Richard N. Jones, Yun Gou, Sarinnapha M. Vasunilashorn, Edward R. Marcantonio, David C. Alsop, Sharon K. Inouye, and Bradford C. Dickerson. “Alzheimer’s-Related Cortical Atrophy Is Associated with Postoperative Delirium Severity in Persons without Dementia.” Neurobiology of Aging 59 (November 2017): 55–63. https://doi.org/10.1016/j.neurobiolaging.2017.07.010.en_US
dc.identifier.issn0197-4580en_US
dc.identifier.issn1558-1497en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369184*
dc.description.abstractPatients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with preclinical AD and postoperative delirium. Participants were older adults (≥70 years) without dementia who underwent preoperative MRI and elective surgery. Delirium incidence and severity were evaluated daily during hospitalization. Cortical thickness was averaged across a published set of a priori brain regions to derive a measure known as the “AD signature.” Logistic and linear regression was used, respectively, to test whether the AD signature was associated with delirium incidence in the entire sample (N=145) or with the severity of delirium among those who developed delirium (N=32). Thinner cortex in the AD signature did not predict incidence of delirium (odds ratio=1.15, p=.38), but was associated with greater delirium severity among those who developed delirium (b=−1.2, p=.014). These results suggest that thinner cortices, perhaps reflecting underlying neurodegeneration due to preclinical AD, may serve as a vulnerability factor that increases severity once delirium occurs.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.neurobiolaging.2017.07.010en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612887/en_US
dash.licenseOAP
dc.titleAlzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementiaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNeurobiology of Agingen_US
dash.depositing.authorAlsop, David
dc.date.available2021-08-30T14:48:30Z
dc.identifier.doi10.1016/j.neurobiolaging.2017.07.010
dc.source.journalNeurobiology of Aging
dash.source.volume59en_US
dash.source.page55-63en_US
dash.contributor.affiliatedVasunilashorn, Sarinnapha
dash.contributor.affiliatedTravison, Thomas
dash.contributor.affiliatedDickerson, Bradford
dash.contributor.affiliatedMarcantonio, Edward
dash.contributor.affiliatedFong, Tamara
dash.contributor.affiliatedAlsop, David
dash.contributor.affiliatedInouye, Sharon


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