dc.contributor.author | Racine, Annie M. | |
dc.contributor.author | Fong, Tamara | |
dc.contributor.author | Travison, Thomas | |
dc.contributor.author | Jones, Richard N. | |
dc.contributor.author | Gou, Yun | |
dc.contributor.author | Vasunilashorn, Sarinnapha | |
dc.contributor.author | Marcantonio, Edward | |
dc.contributor.author | Alsop, David | |
dc.contributor.author | Inouye, Sharon | |
dc.contributor.author | Dickerson, Bradford | |
dc.date.accessioned | 2021-08-30T14:48:30Z | |
dc.date.issued | 2017-11 | |
dc.identifier.citation | Racine, Annie M., Tamara G. Fong, Thomas G. Travison, Richard N. Jones, Yun Gou, Sarinnapha M. Vasunilashorn, Edward R. Marcantonio, David C. Alsop, Sharon K. Inouye, and Bradford C. Dickerson. “Alzheimer’s-Related Cortical Atrophy Is Associated with Postoperative Delirium Severity in Persons without Dementia.” Neurobiology of Aging 59 (November 2017): 55–63. https://doi.org/10.1016/j.neurobiolaging.2017.07.010. | en_US |
dc.identifier.issn | 0197-4580 | en_US |
dc.identifier.issn | 1558-1497 | en_US |
dc.identifier.uri | https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369184 | * |
dc.description.abstract | Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with preclinical AD and postoperative delirium. Participants were older adults (≥70 years) without dementia who underwent preoperative MRI and elective surgery. Delirium incidence and severity were evaluated daily during hospitalization. Cortical thickness was averaged across a published set of a priori brain regions to derive a measure known as the “AD signature.” Logistic and linear regression was used, respectively, to test whether the AD signature was associated with delirium incidence in the entire sample (N=145) or with the severity of delirium among those who developed delirium (N=32). Thinner cortex in the AD signature did not predict incidence of delirium (odds ratio=1.15, p=.38), but was associated with greater delirium severity among those who developed delirium (b=−1.2, p=.014). These results suggest that thinner cortices, perhaps reflecting underlying neurodegeneration due to preclinical AD, may serve as a vulnerability factor that increases severity once delirium occurs. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier BV | en_US |
dc.relation.isversionof | doi:10.1016/j.neurobiolaging.2017.07.010 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612887/ | en_US |
dash.license | OAP | |
dc.title | Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Neurobiology of Aging | en_US |
dash.depositing.author | Alsop, David | |
dc.date.available | 2021-08-30T14:48:30Z | |
dc.identifier.doi | 10.1016/j.neurobiolaging.2017.07.010 | |
dc.source.journal | Neurobiology of Aging | |
dash.source.volume | 59 | en_US |
dash.source.page | 55-63 | en_US |
dash.contributor.affiliated | Vasunilashorn, Sarinnapha | |
dash.contributor.affiliated | Travison, Thomas | |
dash.contributor.affiliated | Dickerson, Bradford | |
dash.contributor.affiliated | Marcantonio, Edward | |
dash.contributor.affiliated | Fong, Tamara | |
dash.contributor.affiliated | Alsop, David | |
dash.contributor.affiliated | Inouye, Sharon | |