Show simple item record

dc.contributor.authorPfefferbaum, Adolf
dc.contributor.authorChanraud, Sandra
dc.contributor.authorPitel, Anne-Lise
dc.contributor.authorShankaranarayanan, Ajit
dc.contributor.authorAlsop, David
dc.contributor.authorRohlfing, Torsten
dc.contributor.authorSullivan, Edith V.
dc.date.accessioned2021-09-03T15:40:16Z
dc.date.issued2010-06-30
dc.identifier.citationPfefferbaum, Adolf, Sandra Chanraud, Anne-Lise Pitel, Ajit Shankaranarayanan, David Alsop, Torsten Rohlfing, Edith V. Sullivan. "Volumetric Cerebral Perfusion Imaging in Healthy Adults: Regional Distribution, Laterality, and Repeatability of Pulsed Continuous Arterial Spin Labeling (PCASL)." Psychiatry Research: Neuroimaging 182, no. 3 (2010): 266-273. DOI: 10.1016/j.pscychresns.2010.02.010
dc.identifier.issn0925-4927en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369295*
dc.description.abstractThe regional distribution, laterality, and reliability of volumetric pulsed continuous arterial spin labeling (PCASL) measurements of cerebral blood flow (CBF) in cortical, subcortical, and cerebellar regions were determined in 10 normal volunteers studied on two occasions separated by 3 to 7 days. Regional CBF, normalized for global perfusion, was highly reliable when measured on separate days. Several regions showed significant lateral asymmetry; notably, in frontal regions CBF was greater in the right than left hemisphere, whereas left was greater than right in posterior regions. There was considerable regional variability across the brain, whereby the posterior cingulate and central and posterior precuneus cortices had the highest perfusion and the globus pallidus the lowest gray matter perfusion. The latter may be due to iron-induced T1 shortening affecting labeled spins and computed CBF signal. High CBF in the posterior cingulate and posterior and central precuneus cortices in this task-free acquisition suggests high activity in these principal nodes of the “default mode network.”en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.pscychresns.2010.02.010en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914847/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Radiological research::Radiologyen_US
dc.subjectResearch Subject Categories::MEDICINE::Psychiatryen_US
dc.subjectResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biology::Neuroscienceen_US
dc.titleVolumetric Cerebral Perfusion Imaging in Healthy Adults: Regional Distribution, Laterality, and Repeatability of Pulsed Continuous Arterial Spin Labeling (PCASL)en_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalPsychiatry Research: Neuroimagingen_US
dash.depositing.authorAlsop, David
dc.date.available2021-09-03T15:40:16Z
dc.identifier.doi10.1016/j.pscychresns.2010.02.010
dc.source.journalPsychiatry Research: Neuroimaging
dash.source.volume182en_US
dash.source.page266-273en_US
dash.source.issue3en_US
dash.contributor.affiliatedAlsop, David


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record