White Matter Hyperintensities and Dynamics of Postural Control
Author
Haertle, Mareile
Zhao, Peng
Novak, Peter
Abduljalil, Amir
Published Version
https://doi.org/10.1016/j.mri.2009.01.010Metadata
Show full item recordCitation
Novak, Vera, Mareile Haertle, Peng Zhao, Kun Hu, Medha Munshi, Peter Novak, Amir Abduljalil et al. "White Matter Hyperintensities and Dynamics of Postural Control." Magnetic Resonance Imaging 27, no. 6 (2009): 752-759. DOI: 10.1016/j.mri.2009.01.010Abstract
BackgroundWhite matter hyperintensities (WMHs) on MRI have been associated with age, cardiovascular risk factors and falls in the elderly. This study evaluated the relationship between WMHs and dynamics of postural control in older adults without history of falls.
Methods
We studied 76 community-living subjects without history of falls (age 64.5±7.3 years). Brain and WMH volume calculations and clinical rating were done on fluid-attenuation inversion recovery (FLAIR) and MP-RAGE MR images on 3 T. Balance was assessed from the center of pressure displacement using the force platform during 3 min of quiet standing using traditional and dynamic measures (using stabilogram-diffusion analysis). Gait speed was measured from 12-min walk.
Results
Age-adjusted periventricular and focal WMHs were associated with changes in certain dynamic balance measures, including reduced range of postural sway in anteroposterior direction (fronto-temporal WMHs, P=.045; parieto-occipital WMHs, P=.009) and more irregular long-term mediolateral fluctuations (P=.046). Normal walking speed was not affected by WMHs.
Conclusions
Periventricular and focal WMHs affect long-term dynamics of postural control, which requires engagement of feedback mechanisms, and may contribute to mobility decline in the elderly.
Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2727871/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369296
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