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dc.contributor.authorNovak, Vera
dc.contributor.authorHaertle, Mareile
dc.contributor.authorZhao, Peng
dc.contributor.authorHu, Kun
dc.contributor.authorMunshi, Medha
dc.contributor.authorNovak, Peter
dc.contributor.authorAbduljalil, Amir
dc.contributor.authorAlsop, David
dc.date.accessioned2021-09-03T16:01:23Z
dc.date.issued2009-07
dc.identifier.citationNovak, Vera, Mareile Haertle, Peng Zhao, Kun Hu, Medha Munshi, Peter Novak, Amir Abduljalil et al. "White Matter Hyperintensities and Dynamics of Postural Control." Magnetic Resonance Imaging 27, no. 6 (2009): 752-759. DOI: 10.1016/j.mri.2009.01.010
dc.identifier.issn0730-725Xen_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369296*
dc.description.abstractBackground White matter hyperintensities (WMHs) on MRI have been associated with age, cardiovascular risk factors and falls in the elderly. This study evaluated the relationship between WMHs and dynamics of postural control in older adults without history of falls. Methods We studied 76 community-living subjects without history of falls (age 64.5±7.3 years). Brain and WMH volume calculations and clinical rating were done on fluid-attenuation inversion recovery (FLAIR) and MP-RAGE MR images on 3 T. Balance was assessed from the center of pressure displacement using the force platform during 3 min of quiet standing using traditional and dynamic measures (using stabilogram-diffusion analysis). Gait speed was measured from 12-min walk. Results Age-adjusted periventricular and focal WMHs were associated with changes in certain dynamic balance measures, including reduced range of postural sway in anteroposterior direction (fronto-temporal WMHs, P=.045; parieto-occipital WMHs, P=.009) and more irregular long-term mediolateral fluctuations (P=.046). Normal walking speed was not affected by WMHs. Conclusions Periventricular and focal WMHs affect long-term dynamics of postural control, which requires engagement of feedback mechanisms, and may contribute to mobility decline in the elderly.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.mri.2009.01.010en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc2727871/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::TECHNOLOGY::Engineering physics::Biophysicsen_US
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Radiological research::Radiologyen_US
dc.subjectResearch Subject Categories::TECHNOLOGY::Other technology::Medical engineeringen_US
dc.titleWhite Matter Hyperintensities and Dynamics of Postural Controlen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalMagnetic Resonance Imagingen_US
dash.depositing.authorAlsop, David
dc.date.available2021-09-03T16:01:23Z
dc.identifier.doi10.1016/j.mri.2009.01.010
dc.source.journalMagnetic Resonance Imaging
dash.source.volume27en_US
dash.source.page752-759en_US
dash.source.issue6en_US
dash.contributor.affiliatedMunshi, Medha
dash.contributor.affiliatedHu, Kun
dash.contributor.affiliatedNovak, Vera
dash.contributor.affiliatedAlsop, David


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