Comparative Genetic Architectures of Schizophrenia in East Asian and European Populations
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Author
Ma, Xixian
Gaspar, Helena
Ikeda, Masashi
Benyamin, Beben
Brown, Brielin C.
Liu, Ruize
Zhou, Wei
Guan, Lili
Kamatani, Yoichiro
Kim, Sung-Wan
Kubo, Michiaki
Kusumawardhani, Agung
Liu, Chih-Min
Ma, Hong
Periyasamy, Sathish
Takahashi, Atsushi
Wang, Qiang
Xu, Zhida
Yu, Hao
Zhu, Feng
Chen, Wei J.
Faraone, Stephen
Glatt, Stephen J.
He, Lin
Hyman, Steven E.
Hwu, Hai-Gwo
Li, Tao
McCarroll, Steven
Neale, Benjamin M.
Sklar, Pamela
Wildenauer, Dieter
Yu, Xin
Zhang, Dai
Mowry, Bryan
Lee, Jimmy
Holmans, Peter
Xu, Shuhua
Sullivan, Patrick F.
Ripke, Stephan
O’Donovan, Michael
Daly, Mark J.
Qin, Shengying
Sham, Pak
Iwata, Nakao
Hong, Kyung S.
Schwab, Sibylle G.
Yue, Weihua
Tsuang, Ming
Liu, Jianjun
Ma, Xiancang
Kahn, René S.
Shi, Yongyong
Bryois, Julien
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https://doi.org/10.1101/445874Metadata
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Lam, Max, Chia-Yen Chen, Shengyin Qin, Pak Sham, Nakao Iwata, Kyung Hong, Sibylle Schwab, Weihua Yue, Ming Tsuang, Jianjun Liu, Xiancang Ma, René Kahn, Yongyong Shi, and Hailiang Huang. 2019. 12 Comparative Genetic Architectures of Schizophrenia in East Asian and European Populations. European Neuropsychopharmacology 29, no. S4: S1073.Abstract
Schizophrenia is a severe psychiatric disorder with a lifetime risk of about 1% world-wide. Most large schizophrenia genetic studies have studied people of primarily European ancestry, potentially missing important biological insights. Here we present a study of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide significant schizophrenia associations in 19 genetic loci. Over the genome, the common genetic variants that confer risk for schizophrenia have highly similar effects in those of East Asian and European ancestry (r=0.98), indicating for the first time that the genetic basis of schizophrenia and its biology are broadly shared across these world populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries revealed 208 genome-wide significant schizophrenia associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping more precisely isolated schizophrenia causal alleles in 70% of these loci. Despite consistent genetic effects across populations, polygenic risk models trained in one population have reduced performance in the other, highlighting the importance of including all major ancestral groups with sufficient sample size to ensure the findings have maximum relevance for all populations.Other Sources
http://doi.org/10.1101/445874Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369298
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