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dc.contributor.authorLam, Max
dc.contributor.authorChen, Chia-Yen
dc.contributor.authorLi, Zhiqiang
dc.contributor.authorMa, Xixian
dc.contributor.authorGaspar, Helena
dc.contributor.authorIkeda, Masashi
dc.contributor.authorBenyamin, Beben
dc.contributor.authorBrown, Brielin C.
dc.contributor.authorLiu, Ruize
dc.contributor.authorZhou, Wei
dc.contributor.authorGuan, Lili
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorKim, Sung-Wan
dc.contributor.authorKubo, Michiaki
dc.contributor.authorKusumawardhani, Agung
dc.contributor.authorLiu, Chih-Min
dc.contributor.authorMa, Hong
dc.contributor.authorPeriyasamy, Sathish
dc.contributor.authorTakahashi, Atsushi
dc.contributor.authorWang, Qiang
dc.contributor.authorXu, Zhida
dc.contributor.authorYu, Hao
dc.contributor.authorZhu, Feng
dc.contributor.authorChen, Wei J.
dc.contributor.authorFaraone, Stephen
dc.contributor.authorGlatt, Stephen J.
dc.contributor.authorHe, Lin
dc.contributor.authorHyman, Steven E.
dc.contributor.authorHwu, Hai-Gwo
dc.contributor.authorLi, Tao
dc.contributor.authorMcCarroll, Steven
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorSklar, Pamela
dc.contributor.authorWildenauer, Dieter
dc.contributor.authorYu, Xin
dc.contributor.authorZhang, Dai
dc.contributor.authorMowry, Bryan
dc.contributor.authorLee, Jimmy
dc.contributor.authorHolmans, Peter
dc.contributor.authorXu, Shuhua
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorRipke, Stephan
dc.contributor.authorO’Donovan, Michael
dc.contributor.authorDaly, Mark J.
dc.contributor.authorQin, Shengying
dc.contributor.authorSham, Pak
dc.contributor.authorIwata, Nakao
dc.contributor.authorHong, Kyung S.
dc.contributor.authorSchwab, Sibylle G.
dc.contributor.authorYue, Weihua
dc.contributor.authorTsuang, Ming
dc.contributor.authorLiu, Jianjun
dc.contributor.authorMa, Xiancang
dc.contributor.authorKahn, René S.
dc.contributor.authorShi, Yongyong
dc.contributor.authorHuang, Hailiang
dc.contributor.authorMartin, Alicia
dc.contributor.authorBryois, Julien
dc.date.accessioned2021-09-03T16:06:40Z
dc.date.issued2018-10-17
dc.identifier.citationLam, Max, Chia-Yen Chen, Shengyin Qin, Pak Sham, Nakao Iwata, Kyung Hong, Sibylle Schwab, Weihua Yue, Ming Tsuang, Jianjun Liu, Xiancang Ma, René Kahn, Yongyong Shi, and Hailiang Huang. 2019. 12 Comparative Genetic Architectures of Schizophrenia in East Asian and European Populations. European Neuropsychopharmacology 29, no. S4: S1073.en_US
dc.identifier.issn0924-977Xen_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369298*
dc.description.abstractSchizophrenia is a severe psychiatric disorder with a lifetime risk of about 1% world-wide. Most large schizophrenia genetic studies have studied people of primarily European ancestry, potentially missing important biological insights. Here we present a study of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide significant schizophrenia associations in 19 genetic loci. Over the genome, the common genetic variants that confer risk for schizophrenia have highly similar effects in those of East Asian and European ancestry (r<jats:sub>g</jats:sub>=0.98), indicating for the first time that the genetic basis of schizophrenia and its biology are broadly shared across these world populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries revealed 208 genome-wide significant schizophrenia associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping more precisely isolated schizophrenia causal alleles in 70% of these loci. Despite consistent genetic effects across populations, polygenic risk models trained in one population have reduced performance in the other, highlighting the importance of including all major ancestral groups with sufficient sample size to ensure the findings have maximum relevance for all populations.en_US
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratoryen_US
dc.relationNature Geneticsen_US
dc.relation.isversionofdoi: 10.1016/j.euroneuro.2018.08.019en_US
dc.relation.hasversionhttp://doi.org/10.1101/445874en_US
dash.licenseLAA
dc.subjectPharmacology (medical)en_US
dc.subjectBiological Psychiatryen_US
dc.subjectPharmacologyen_US
dc.subjectNeurologyen_US
dc.subjectPsychiatry and Mental healthen_US
dc.subjectClinical Neurologyen_US
dc.titleComparative Genetic Architectures of Schizophrenia in East Asian and European Populationsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalEuropean Neuropsychopharmacologyen_US
dash.depositing.authorHuang, Hailiang
dash.waiver2019-07-10
dc.date.available2021-09-03T16:06:40Z
dash.affiliation.otherHarvard Medical Schoolen_US
dc.identifier.doi10.1101/445874
dc.source.journalEuropean Neuropsychopharmacology
dash.source.pageS1073en_US
dash.contributor.affiliatedLam, Max
dash.contributor.affiliatedLi, Zhiqiang
dash.contributor.affiliatedChen, Chia-Yen
dash.contributor.affiliatedHuang, Hailiang
dash.contributor.affiliatedMartin, Alicia


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