Head Circumference as a Useful Surrogate for Intracranial Volume in Older Adults
Author
Fox, Meaghan L.
Kosar, Cyrus M.
Schmitt, Eva M.
Jones, Richard N.
Published Version
https://doi.org/10.1017/s104161021500037xMetadata
Show full item recordCitation
Hshieh, Tammy, Meaghan L. Fox, Cyrus M. Kosar, Michele Cavallari, Charles Guttmann, David Alsop, Edward Marcantonio et al. "Head Circumference as a Useful Surrogate for Intracranial Volume in Older Adults." International Psychogeriatrics 28, no. 1 (2016): 157-162. DOI: 10.1017/s104161021500037xAbstract
BackgroundIntracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined head circumference as a useful surrogate for intracranial volume in older adults.
Methods
99 older adults underwent Magnetic Resonance Imaging (MRI). ICV was measured by Statistical Parametric Mapping 8 (SPM8) software or Functional MRI of the Brain Software Library (FSL) extraction with manual editing, typically considered the gold standard. Head circumferences were determined using standardized tape measurement. We examined estimated correlation coefficients between head circumference and the two MRI-based ICV measurements.
Results
Head circumference and ICV by SPM8 were moderately correlated (overall r=0.73, men r=0.67, women r=0.63). Head circumference and ICV by FSL were also moderately correlated (overall r=0.69, men r=0.63, women r=0.49).
Conclusions
Head circumference measurement was strongly correlated with MRI-derived ICV. Our study presents a simple method to approximate ICV among older patients, which may prove useful as a surrogate for cognitive reserve in large scale epidemiologic studies of cognitive outcomes. This study also suggests the stability of head circumference correlation with ICV throughout the lifespan.
Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669896/Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369350
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