Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster
Author
Katewa, Subhash D.
Demontis, Fabio
Kolipinski, Marysia
Hubbard, Alan
Gill, Matthew S.
Melov, Simon
Kapahi, Pankaj
Published Version
https://doi.org/10.1016/j.cmet.2012.06.005Metadata
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Katewa, Subhash D., Fabio Demontis, Marysia Kolipinski, Alan Hubbard, Matthew S. Gill, Norbert Perrimon, Simon Melov et al. "Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster." Cell Metabolism 16, no. 1 (2012): 97-103. DOI: 10.1016/j.cmet.2012.06.005Abstract
Changes in fat content have been associated with dietary restriction (DR), but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism towards increasing both fatty acid synthesis and breakdown, which is required for various responses to DR. Inhibition of fatty acid synthesis or oxidation genes specifically in the muscle tissue inhibited lifespan extension upon DR. Furthermore, DR enhances spontaneous activity of flies which was found to be dependent on the enhanced fatty acid metabolism. This increase in activity was found to be at least partially required for the lifespan extension upon DR. Over-expression of adipokinetic hormone (dAKH), the functional ortholog of glucagon, enhances fat metabolism, spontaneous activity and lifespan. Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400463/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369690
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