Mechanisms of Muscle Growth and Atrophy in Mammals and Drosophila
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CitationPiccirillo, Rosanna, Fabio Demontis, Norbert Perrimon, Alfred Goldberg. "Mechanisms of Muscle Growth and Atrophy in Mammals and Drosophila." Developmental Dynamics 243, no. 2 (2014): 201-215. DOI: 10.1002/dvdy.24036
AbstractThe loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369714
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