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dc.contributor.authorPitsouli, Chrysoula
dc.contributor.authorPerrimon, Norbert
dc.date.accessioned2021-10-08T13:55:01Z
dc.date.issued2010-11-01
dc.identifier.citationPitsouli, Chrysoula, Norbert Perrimon. "Embryonic Multipotent Progenitors Remodel the Drosophila Airways During Metamorphosis." Development 137, no. 21 (2010): 3615-3624. DOI: 10.1242/dev.056408
dc.identifier.issn0950-1991en_US
dc.identifier.issn1477-9129en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369735*
dc.description.abstractAdult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until the larval stages, when they proliferate and differentiate to form organs. The Drosophila tracheal system is extensively remodeled during metamorphosis by a small number of airway progenitors. Among these, the spiracular branch tracheoblasts are responsible for the generation of the pupal and adult abdominal airways. To understand the coordination of proliferation and differentiation during organogenesis of tubular organs, we analyzed the remodeling of Drosophila airways during metamorphosis. We show that the embryonic spiracular branch tracheoblasts are multipotent cells that express the homeobox transcription factor Cut, which is necessary for their survival and normal development. They give rise to three distinct cell populations at the end of larval development, which generate the adult tracheal tubes, the spiracle and the epidermis surrounding the spiracle. Our study establishes the series of events that lead to the formation of an adult tubular structure in Drosophila.en_US
dc.language.isoen_USen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.isversionofdoi:10.1242/dev.056408en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964094/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biologyen_US
dc.titleEmbryonic Multipotent Progenitors Remodel the Drosophila Airways During Metamorphosisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDevelopmenten_US
dash.depositing.authorPerrimon, Norbert
dc.date.available2021-10-08T13:55:01Z
dc.identifier.doi10.1242/dev.056408
dc.source.journalDevelopment
dash.source.volume137en_US
dash.source.page3615-3624en_US
dash.source.issue21en_US
dash.contributor.affiliatedPerrimon, Norbert


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