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dc.contributor.authorGleeson, T.
dc.contributor.authorIversen, Maura Daly
dc.contributor.authorAvorn, Jerry Lewis
dc.contributor.authorBrookhart, A. M.
dc.contributor.authorKatz, Jeffrey Neil
dc.contributor.authorLosina, Elena
dc.contributor.authorMay, F.
dc.contributor.authorPatrick, A. R.
dc.contributor.authorShrank, W
dc.contributor.authorSolomon, Daniel Hal
dc.contributor.authorSolomon, Daniel Hal
dc.date.accessioned2021-12-13T16:41:31Z
dc.date.issued2009-06-05
dc.identifier.citationGleeson, T., M. D. Iversen, J. Avorn, A. M. Brookhart, J. N. Katz, E. Losina, F. May, A. R. Patrick, W. H. Shrank, and D. H. Solomon. 2009. Interventions to Improve Adherence and Persistence with Osteoporosis Medications: a Systematic Literature Review. Osteoporos Int 20, no. 12: 2127–2134. doi:10.1007/s00198-009-0976-0. http://dx.doi.org/10.1007/s00198-009-0976-0.en_US
dc.identifier.issn0937-941Xen_US
dc.identifier.issn1433-2965en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370429*
dc.description.abstractSummary: Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met eligibility requirements and were included in the review. Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial. Introduction: Adherence and persistence with pharmacologic therapy for osteoporosis are suboptimal. Our goal was to examine the design and efficacy of published interventions to improve adherence and persistence. Methods: We searched medical literature databases for English-language papers published between January 1990 and July 2008. We selected papers that described interventions and provided results for control and intervention subjects. We assessed the design and methods of each study, including randomization, blinding, and reporting of drop-outs. We summarized the results and calculated effect sizes for each trial. Results: Seven studies met eligibility requirements and were included in the review. Five of the seven studies provided adherence data. Of those five studies, three showed a statistically significant (p≤0.05) improvement in adherence by the intervention group, with effect sizes from 0.17 to 0.58. Five of the seven studies provided persistence data. Of those five, one reported statistically significant improvement in persistence by the intervention group, with an effect size of 0.36. Conclusions: Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified in this small sample of studies. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/s00198-009-0976-0en_US
dc.relation.hasversionhttp://pubmed.ncbi.nlm.nih.gov/19499273/en_US
dash.licenseMETA_ONLY
dc.subjectadherenceen_US
dc.subjectcomplianceen_US
dc.subjectinterventionen_US
dc.subjectmedicationen_US
dc.subjectmotivational interviewingen_US
dc.subjectosteoporosisen_US
dc.subjectpersistenceen_US
dc.subjectsystematic reviewen_US
dc.titleInterventions to Improve Adherence and Persistence With Osteoporosis Medications: A Systematic Literature Reviewen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalOsteoporosis Internationalen_US
dash.depositing.authorKatz, Jeffrey Neil
dc.date.available2021-12-13T16:41:31Z
dc.identifier.doi10.1007/s00198-009-0976-0*
dash.source.volume20en_US
dash.source.page2127-2134en_US
dash.source.issue12en_US
dash.contributor.affiliatedIversen, Maura
dash.contributor.affiliatedSolomon, Daniel
dash.contributor.affiliatedShrank, William
dash.contributor.affiliatedAvorn, Jerome
dash.contributor.affiliatedLosina, Elena
dash.contributor.affiliatedKatz, Jeffrey


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