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dc.contributor.authorGordon, Joanne C.
dc.contributor.authorHolt, Natalie C.
dc.contributor.authorBiewener, Andrew
dc.contributor.authorDaley, Monica A.
dc.date.accessioned2022-03-09T17:10:20Z
dc.date.issued2019-11-25
dc.identifier.citationGordon, Joanne C, Holt, Natalie C, Biewener, Andrew A, and Daley, Monica A. "Tuning of Feedforward Control Enables Stable Muscle Force-length Dynamics after Loss of Autogenic Proprioceptive Feedback." ELife 9 (2020): ELife, 2020-06-23.en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370968*
dc.description.abstractAnimals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force and work output to minimize perturbations in uneven terrain. Here we probe the role of reflexes in the rapid perturbation responses of muscle by studying the effects of proprioceptive loss. We induced bilateral loss of autogenic proprioception in the lateral gastrocnemius muscle (LG) using self-reinnervation. We compared in vivo muscle dynamics and ankle kinematics in birds with reinnervated and intact LG. Reinnervated and intact LG exhibit similar steady state mechanical function and similar work modulation in response to obstacle encounters. Reinnervated LG exhibits 23ms earlier steady-state activation, consistent with feedforward tuning of activation phase to compensate for lost proprioception. Modulation of activity duration is impaired in rLG, confirming the role of reflex feedback in regulating force duration in intact muscle.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratoryen_US
dc.relationeLifeen_US
dash.licenseOAP
dc.subjectstabilityen_US
dc.subjectintrinsic mechanicsen_US
dc.subjectpassive-dynamicsen_US
dc.subjectreflexesen_US
dc.subjectfeedbacken_US
dc.subjectfeedforwarden_US
dc.subjectelectromyographyen_US
dc.subjectrunningen_US
dc.subjectlocomotionen_US
dc.subjectin vivo muscle work loopen_US
dc.subjectguinea fowlen_US
dc.titleTuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedbacken_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalELifeen_US
dash.depositing.authorBiewener, Andrew
dc.date.available2022-03-09T17:10:20Z
dc.identifier.doi10.1101/851626
dash.contributor.affiliatedBiewener, Andrew


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