Show simple item record

dc.contributor.authorXu, Miao
dc.contributor.authorYao, Youyuan
dc.contributor.authorChen, Hui
dc.contributor.authorZhang, Shanshan
dc.contributor.authorCao, Su-Mei
dc.contributor.authorZhang, Zhe
dc.contributor.authorLuo, Bing
dc.contributor.authorLiu, Zhiwei
dc.contributor.authorLi, Zilin
dc.contributor.authorXiang, Tong
dc.contributor.authorHe, Guiping
dc.contributor.authorFeng, Qi-Sheng
dc.contributor.authorChen, Li-Zhen
dc.contributor.authorGuo, Xiang
dc.contributor.authorJia, Wei-Hua
dc.contributor.authorChen, Ming-Yuan
dc.contributor.authorZhang, Xiao
dc.contributor.authorXie, Shang-Hang
dc.contributor.authorPeng, Roujun
dc.contributor.authorChang, Ellen T.
dc.contributor.authorPedergnana, Vincent
dc.contributor.authorFeng, Lin
dc.contributor.authorBei, Jin-Xin
dc.contributor.authorXu, Rui-Hua
dc.contributor.authorZeng, Mu-Sheng
dc.contributor.authorYe, Weimin
dc.contributor.authorAdami, Hans-Olov
dc.contributor.authorLin, Xihong
dc.contributor.authorZhai, Weiwei
dc.contributor.authorZeng, Yi-Xin
dc.contributor.authorLiu, Jianjun
dc.date.accessioned2022-03-17T16:00:11Z
dc.date.issued2019-06-17
dc.identifier.citationXu, M., Y. Yao, H. Chen, et al. 2019. Genome Sequencing Analysis Identifies Epstein-Barr Virus Subtypes Associated with High Risk of Nasopharyngeal Carcinoma. Nature Genetics 51, no. 7: 1131.en_US
dc.identifier.issn1061-4036en_US
dc.identifier.issn1546-1718en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37371086*
dc.description.abstractEpstein-Barr virus (EBV) infection is ubiquitous worldwide and associated with multiple cancers including nasopharyngeal carcinoma (NPC). The role of EBV viral genomic variation in NPC development and its striking endemicity in southern China has been poorly explored. Through large-scale genome sequencing and association study of EBV isolates from China, we identified two non-synonymous EBV variants within BALF2 strongly associated with NPC risk (conditional P value 1.75 X 10-6 for SNP162476_C and 3.23 X 10-13 for SNP163364_T), whose cumulative effects contributed to 83% of the overall risk in southern China. Phylogenetic analysis of the risk variants revealed a unique origin in southern China followed by clonal expansion. EBV BALF2 haplotype carrying the risk variants were shown to reduce viral lytic DNA replication, as a result potentially promoting viral latency. Our discovery has not only provided insight to the unique endemic pattern of NPC occurrence in southern China, but also paved the way for the identification of individuals at high risk of NPC and effective intervention program to reduce the disease burden in southern China.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relationGenome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinomaen_US
dc.relation.hasversionhttps://www-ncbi-nlm-nih-gov.ezp-prod1.hul.harvard.edu/pmc/articles/PMC6610787/en_US
dash.licenseLAA
dc.subjectGeneticsen_US
dc.titleGenome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinomaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNature Geneticsen_US
dash.depositing.authorLin, Xihong
dash.waiver2019-04-03
dc.date.available2022-03-17T16:00:11Z
dash.affiliation.otherHarvard T.H. Chan School of Public Healthen_US
dc.identifier.doi10.1038/s41588-019-0436-5
dc.source.journalNat Genet
dash.waiver.reasonRequest from Nature Geneticsen_US
dash.source.volume51en_US
dash.source.page1131-1136en_US
dash.source.issue7en_US
dash.contributor.affiliatedXu, Miao
dash.contributor.affiliatedAdami, Hans-Olov
dash.contributor.affiliatedLi, Zilin
dash.contributor.affiliatedLin, Xihong


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record