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dc.contributor.authorStankiewicz, James
dc.contributor.authorNeema, Mohit
dc.contributor.authorAlsop, David
dc.contributor.authorHealy, Brian
dc.contributor.authorArora, Ashish
dc.contributor.authorBuckle, Guy J.
dc.contributor.authorChitnis, Tanuja
dc.contributor.authorGuttmann, Charles
dc.contributor.authorHackney, David
dc.contributor.authorBakshi, Rohit
dc.date.accessioned2022-04-22T15:08:14Z
dc.date.issued2009-04-15
dc.identifier.citationStankiewicz, James, Mohit Neema, David Alsop, Brian Healy, Ashish Arora, Guy J. Buckle, Tanuja Chitnis et al. "Spinal Cord Lesions and Clinical Status in Multiple Sclerosis: A 1.5 T and 3 T MRI Study." Journal of the Neurological Sciences 279, no. 1-2 (2009): 99-105. DOI: 10.1016/j.jns.2008.11.009
dc.identifier.issn0022-510Xen_US
dc.identifier.issn1878-5883en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37371442*
dc.description.abstractObjective Assess the relationship between spinal cord T2 hyperintense lesions and clinical status in multiple sclerosis (MS) with 1.5 and 3T MRI. Methods Whole cord T2-weighted fast spin-echo MRI was performed in 32 MS patients [Expanded Disability Status Scale (EDSS) score (mean±SD: 2±1.9), range 0–6.5]. Protocols at 1.5T and 3T were optimized and matched on voxel size. Results Moderate correlations were found between whole cord lesion volume and EDSS score at 1.5T (rs =.36, p=0.04), but not at 3T (rs =0.13, p=0.46). Pyramidal Functional System Score (FSS) correlated with thoracic T2 lesion number (rs=.46, p=0.01) and total spinal cord lesion number (rs=0.37, p=0.04) and volume (rs=0.37, p=0.04) at 1.5T. Bowel/bladder FSS correlated with T2 lesion volume and number in the cervical, thoracic, and total spine at 1.5T (rs 0.400.57, all p<0.05). These MRI-FSS correlations were non-significant at 3T. However, these correlation coefficients did not differ significantly between platforms (Choi’s test p>0.05). Correlations between whole cord lesion volume and timed 25-foot walk were non-significant at 1.5T and 3T (p>0.05). Lesion number and volume did not differ between MRI platforms in the MS group (p>0.05). Conclusions Despite the use of higher field MRI strength, the link between spinal lesions and MS disability remains weak. The 1.5T and 3T protocols yielded similar results for many comparisons.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.jns.2008.11.009en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679653/en_US
dash.licenseLAA
dc.subjectClinical Neurologyen_US
dc.subjectNeurologyen_US
dc.titleSpinal Cord Lesions and Clinical Status in Multiple Sclerosis: A 1.5 T and 3 T MRI Studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJournal of the Neurological Sciencesen_US
dash.depositing.authorChitnis, Tanuja
dc.date.available2022-04-22T15:08:14Z
dc.identifier.doi10.1016/j.jns.2008.11.009
dc.source.journalJournal of the Neurological Sciences
dash.source.volume279en_US
dash.source.page99-105en_US
dash.source.issue1-2en_US
dash.contributor.affiliatedStankiewicz, James
dash.contributor.affiliatedHackney, David
dash.contributor.affiliatedHealy, Brian
dash.contributor.affiliatedAlsop, David
dash.contributor.affiliatedGuttmann, Charles
dash.contributor.affiliatedBakshi, Rohit
dash.contributor.affiliatedChitnis, Tanuja


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