Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
Flax, Judy F.
Benasich, April A.
Detre, John A.
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CitationWang, Ze, María Fernández-Seara, David Alsop, Wen-Ching Liu, Judy F. Flax, April A. Benasich, John A. Detre. "Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI." NeuroImage 39, no. 3 (2008): 973-978. DOI: 10.1016/j.neuroimage.2007.09.045
AbstractArterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for longitudinal imaging of regional brain function in infants. In the present study, continuous ASL (CASL) perfusion MRI was carried out in normally developing 7- and 13-month old infants while asleep without sedation. The 13-month infant group showed an increase (P<0.05) of relative CBF in frontal regions as compared to the 7-month group using a region of interest based analysis. Using a machine-learning algorithm to automatically classify the relative CBF maps of the two infant groups, a significant (P<0.05, permutation testing) regional CBF increase was found in the hippocampi, anterior cingulate, amygdalae, occipital lobes, and auditory cortex in the 13-month old infants. These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37371447
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