Implications of V. cholerae serotypes for vaccine development and infection outcomes
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CitationFakoya, Bolutife. 2022. Implications of V. cholerae serotypes for vaccine development and infection outcomes. Doctoral dissertation, Harvard University Graduate School of Arts and Sciences.
AbstractVibrio cholerae, the cause of the diarrheal disease cholera, remains a major threat to
global public health with approximately 3 million cases reported annually. V. cholerae colonize
the human small intestine and possess a range of virulence factors that enable robust colonization
of susceptible populations. Cholera vaccines are emerging as important tools for cholera
prevention, but different vaccines (depending on their formulations) provide varying levels of
protection against the major Ogawa and Inaba serotypes of V. cholerae. Here we describe how
we used our knowledge of V. cholerae serotypes to optimize the immunogenicity and cross protective
efficacy of a novel live-attenuated cholera vaccine, refine a murine model of V.
cholerae intestinal colonization for evaluating cholera vaccine efficacy, imagine a new paradigm
for global cholera challenge studies, and investigate the role that O-antigen modification plays in
defining both host and pathogen responses to infection. In summary, we characterize critical
translational aspects of cholera vaccine development and elucidate the implications of V.
cholerae serotypes on infection outcomes.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372135
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