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dc.contributor.authorJodoin, Jeanne N.
dc.contributor.authorCoravos, Jonathan S.
dc.contributor.authorChanet, Soline
dc.contributor.authorVasquez, Claudia G.
dc.contributor.authorTworoger, Michael
dc.contributor.authorKingston, Elena R.
dc.contributor.authorPerkins, Lizabeth A.
dc.contributor.authorPerrimon, Norbert
dc.contributor.authorMartin, Adam C.
dc.date.accessioned2022-07-05T14:11:10Z
dc.date.issued2015-12-21
dc.identifier.citationJodoin, Jeanne N., Jonathan S. Coravos, Soline Chanet, Claudia G. Vasquez, Michael Tworoger, Elena R. Kingston, Lizabeth A. Perkins et al. "Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover." Developmental Cell 35, no. 6 (2015): 685-697. DOI: 10.1016/j.devcel.2015.11.018
dc.identifier.issn1534-5807en_US
dc.identifier.issn1878-1551en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372468*
dc.description.abstractThe propagation of force in epithelial tissues requires that the contractile cytoskeletal machinery be stably connected between cells through E-cadherin-containing adherens junctions. In many epithelial tissues the cells’ contractile network is positioned at a distance from the junction. However, the mechanism(s) that connect the contractile networks to the adherens junctions, and thus mechanically connect neighboring cells, is poorly understood. Here, we identified the role for F-actin turnover in regulating the contractile cytosketal network’s attachment to adherens junctions. Perturbing F-actin turnover via gene depletion or acute drug treatments that slow F-actin turnover destabilized the attachment between the contractile actomyosin network and adherens junctions. Our work identifies a critical role for F-actin turnover in connecting actomyosin to intercellular junctions, defining a dynamic process required for the stability of force balance across intercellular contacts in tissues.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.devcel.2015.11.018en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699402/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biologyen_US
dc.titleStable Force Balance between Epithelial Cells Arises from F-Actin Turnoveren_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalDevelopmental Cellen_US
dash.depositing.authorPerrimon, Norbert
dc.date.available2022-07-05T14:11:10Z
dc.identifier.doi10.1016/j.devcel.2015.11.018
dc.source.journalDevelopmental Cell
dash.source.volume35en_US
dash.source.page685-697en_US
dash.source.issue6en_US
dash.contributor.affiliatedPerrimon, Norbert


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